Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Tong-Xing WangYong-Xiang Zhang

Abstract

Growing evidence shows that the neuroendocrine immunomodulation (NIM) network plays an important role in maintaining and modulating body function and the homeostasis of the internal environment. The disequilibrium of NIM in the body is closely associated with many diseases. In the present study, we first collected a core dataset of NIM signaling molecules based on our knowledge and obtained 611 NIM signaling molecules. Then, we built a NIM molecular network based on the MetaCore database and analyzed the signaling transduction characteristics of the core network. We found that the endocrine system played a pivotal role in the bridge between the nervous and immune systems and the signaling transduction between the three systems was not homogeneous. Finally, employing the forest algorithm, we identified the molecular hub playing an important role in the pathogenesis of rheumatoid arthritis (RA) and Alzheimer's disease (AD), based on the NIM molecular network constructed by us. The results showed that GSK3B, SMARCA4, PSMD7, HNF4A, PGR, RXRA, and ESRRA might be the key molecules for RA, while RARA, STAT3, STAT1, and PSMD14 might be the key molecules for AD. The molecular hub may be a potentially druggable target for these two compl...Continue Reading

References

Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P L McGeerE G McGeer
Jan 10, 2002·European Journal of Human Genetics : EJHG·C ForsellL Lannfelt
Jan 30, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erin Luedecking-ZimmerM Ilyas Kamboh
Oct 23, 2003·Clinical Science·Masato IshizukaHironobu Sasano
Dec 19, 2003·Nucleic Acids Research·Rolf ApweilerLai-Su L Yeh
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gang ChenJia Luo
Aug 3, 2004·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Chen-Hsiang YeangTommi Jaakkola
Jun 10, 2005·European Journal of Human Genetics : EJHG·Mia PirskanenHilkka Soininen
Dec 28, 2005·Neuroscience Letters·G SantpereI Ferrer
Jan 24, 2006·Dementia and Geriatric Cognitive Disorders·Ignacio MateoOnofre Combarros
Apr 8, 2006·Nature Biotechnology·Roded Sharan, Trey Ideker
Apr 25, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Salvatore CuzzocreaChristoph Thiemermann
Sep 19, 2006·Neuroscience Letters·Julia HolzapfelHeike Kölsch
Mar 9, 2007·Nature Biotechnology·Kasper LageSøren Brunak
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kwang-Il GohAlbert-László Barabási
Oct 9, 2007·Nature Biotechnology·Andrew L Hopkins
Nov 17, 2007·Bioinformatics·Yassen AssenovMario Albrecht
Apr 29, 2008·Journal of Neurology·S HelisalmiH Soininen
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Jul 29, 2008·Bioinformatics·Jing ZhangShao Li
Apr 21, 2009·Journal of Cellular and Molecular Medicine·Heike KölschReinhard Heun
May 29, 2009·Genetic Testing and Molecular Biomarkers·Rivka Dresner-PollakArthur Pollak
Jan 22, 2010·PLoS Computational Biology·Oron VanunuRoded Sharan
Dec 7, 2010·Cell·Uri David AkaviaDana Pe'er
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·M Bailly-BechetR Zecchina
Mar 11, 2011·PLoS Computational Biology·Yoo-Ah KimTeresa M Przytycka
Mar 26, 2011·Arthritis Research & Therapy·Anak A S S K DharmapatniDavid R Haynes
May 6, 2011·Proceedings of the American Thoracic Society·Joseph Loscalzo
Jul 19, 2011·Scandinavian Journal of Rheumatology·V DziedziejkoA Pawlik
Nov 9, 2011·Methods in Molecular Biology·Paula de MatosChristoph Steinbeck
Feb 7, 2013·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Nurcan TuncbagErnest Fraenkel

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Datasets Mentioned

BETA
GSE63061

Methods Mentioned

BETA
chip

Software Mentioned

NetworkAnalyzer
The Database for Annotation , Visualization and Integrated Dis...
GEO
GEO2R
Cytoscape
NIMNT
Omics integrator

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