Knowledge integration at the center of genomic medicine.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Muin J KhourySheri D Schully

Abstract

Three articles in this issue of Genetics in Medicine describe examples of "knowledge integration," involving methods for generating and synthesizing rapidly emerging information on health-related genomic technologies and engaging stakeholders around the evidence. Knowledge integration, the central process in translating genomic research, involves three closely related, iterative components: knowledge management, knowledge synthesis, and knowledge translation. Knowledge management is the ongoing process of obtaining, organizing, and displaying evolving evidence. For example, horizon scanning and "infoveillance" use emerging technologies to scan databases, registries, publications, and cyberspace for information on genomic applications. Knowledge synthesis is the process of conducting systematic reviews using a priori rules of evidence. For example, methods including meta-analysis, decision analysis, and modeling can be used to combine information from basic, clinical, and population research. Knowledge translation refers to stakeholder engagement and brokering to influence policy, guidelines and recommendations, as well as the research agenda to close knowledge gaps. The ultrarapid production of information requires adequate pub...Continue Reading

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May 21, 2010·Clinical Pharmacology and Therapeutics·M J Khoury
Sep 3, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·David L VeenstraWylie Burke
Dec 30, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Wylie BurkeUNKNOWN Ickworth Group
Jan 15, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Marta GwinnMuin J Khoury
Jan 21, 2011·The New England Journal of Medicine·Jim McDermott
Jan 28, 2011·The New England Journal of Medicine·Ultan McDermottMichael R Stratton
Feb 11, 2011·Nature·Eric D GreenUNKNOWN National Human Genome Research Institute
May 6, 2011·American Journal of Preventive Medicine·Gunther Eysenbach
Jul 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Muin J KhourySheri D Schully
Nov 30, 2011·Genetic Epidemiology·Muin J KhouryWei Yu
Dec 7, 2011·Science·John P A Ioannidis, Muin J Khoury
Jan 13, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sheri D SchullyMuin J Khoury
Feb 16, 2012·PLoS Currents·Luisa Boldrin, Jennifer E Morgan
Apr 7, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Patricia A DeverkaScott D Ramsey
Apr 7, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Byron C WallaceThomas A Trikalinos
Apr 21, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Katrina A B GoddardDavid L Veenstra
Jun 16, 2012·Perspectives in Public Health·Michael P Kelly
Jul 17, 2012·Journal of Genetic Counseling·Brenda FinucaneAllyn McConkie-Rosell

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Citations

Jan 15, 2013·Pediatric Research·Olaf WolkenhauerOlaf Dammann
Sep 6, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Fashoyin-AjeJ Bodurtha
Jan 17, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tram Kim LamMuin J Khoury
Jun 19, 2013·PloS One·John P A IoannidisMuin J Khoury
Mar 6, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sabine M OishiMaren T Scheuner
Apr 23, 2016·Global Heart·Emmanuel PeprahUNKNOWN H3Africa Cardiovascular Diseases Working Group and as members of the H3Africa Consortium
Mar 15, 2015·American Journal of Epidemiology·Robert A Hiatt
Mar 15, 2015·American Journal of Epidemiology·Tram Kim LamSheri D Schully
Nov 29, 2014·Science·Muin J Khoury, John P A Ioannidis
Oct 22, 2014·PLoS Medicine·John P A Ioannidis
Jan 8, 2019·Nuclear Medicine Communications·Issa Loutfi
Jan 12, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·James P Evans, Muin J Khoury
May 28, 2019·BMJ Open·Philip HinesMarisa Papaluca-Amati
Apr 29, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Susan M WolfUNKNOWN LawSeq Framework Task Force
Oct 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·John P A IoannidisMuin J Khoury

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