PMID: 8967780Mar 1, 1996Paper

Known HPV types have no association with keratoacanthomas

Archives of Dermatological Research
S Lu Syrjänen

Abstract

Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated paraffin-embedded specimens of 80 biopsies of KAs for the presence of HPV 1, 2, 3, 4, 5, 7, 26, 37, 38, 47 and 59 DNA by in situ hybridization (ISH) with biotinylated probes under high stringency conditions (Tm-10 degrees C). Every fourth biopsy specimens was also examined by polymerase chain reaction (PCR) with consensus primers targeting the HPV E1 and L1 regions. The positive cases were further studied by direct DNA sequencing. All specimens proved to be negative for all HPV DNAs studied by ISH. Three out of 20 cases produced in positive PCR amplifications when consensus primers targeting the L1 region were used. However, the same samples remained negative with general primers targeting the E1 region. The DNA sequence analysis of the PCR-positive products showed a 76% homology with HPV type 17. Our results suggest that the known HPV types are unlikely to have any role in the aetiology of KAs.

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Citations

Jul 30, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M NiebuhrT Werfel
May 1, 1997·Clinics in Dermatology·H Pfister, J Ter Schegget
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Jun 2, 2011·International Journal of Cancer. Journal International Du Cancer·Johanna EkströmJoakim Dillner
Mar 23, 2011·The British Journal of Dermatology·S Tuttleton ArronUNKNOWN Viral Working Group of the International Transplant Skin Cancer Collaborative (ITSCC) & Skin Care in Organ Transplant Patien
Feb 13, 2003·Journal of the American Academy of Dermatology·Sean F Pattee, Nancy G Silvis
Mar 16, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anthony M RossiKishwer S Nehal
Oct 24, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U R HenggeA Marini
Jul 16, 2003·Journal of Cutaneous Pathology·Ola ForslundOle Petter F Clausen

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