Knowns and unknowns in the future of multiple sclerosis treatment

Journal of the Neurological Sciences
Olaf Stüve

Abstract

Multiple sclerosis is a chronic disease confined to the central nervous system. Its pathological hallmarks are neuroinflammation, de- and re-myelination, neurodegeneration and astrogliosis. The aetiology of multiple sclerosis is unknown, although a growing body of evidence supports an autoimmune pathogenesis triggered by environmental factors in genetically susceptible individuals. It is therefore perhaps unsurprising that immunomodulatory therapies have now been the mainstay of pharmacotherapy and the focus for the search for a cure for many decades. Currently, clinicians have access to two distinct treatment strategies, namely general immunomodulation or immunosuppression. During the last two decades, several immunomodulatory agents and one immunosuppressant drug have been shown to be effective in clinical trials and have been approved on this basis for the treatment of multiple sclerosis. Current drugs offer well-established safe and effective therapeutic agents for multiple sclerosis in both the short and long term. More recently, growing knowledge of specific anatomical, cellular and molecular targets that play critical roles in the inflammatory cascade of multiple sclerosis have shifted the focus of drug development towar...Continue Reading

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Citations

Dec 15, 2010·Drug Design, Development and Therapy·Laurie J BartenMichael P Rivey
Mar 31, 2011·Patient Preference and Adherence·Nathalie Girouard, Nanda Soucy
Jan 29, 2010·Journal of the Neurological Sciences·Thomas Berger
Jul 22, 2019·Journal of Korean Medical Science·Il Han YooSuk Won Ahn
Jan 9, 2018·Expert Opinion on Biological Therapy·Jennifer R EvanFrancesca Bagnato
Jun 6, 2017·Journal of Neuroscience Research·Heather YongJacqueline Quandt

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