KNUCKLES (KNU) encodes a C2H2 zinc-finger protein that regulates development of basal pattern elements of the Arabidopsis gynoecium

Development
Thomas PayneAnna M Koltunow

Abstract

Flowers of the parthenocarpic knuckles mutant are conditionally male sterile and contain ectopic stamens and carpels that originate from placental tissue within developing gynoecia. The mutation was mapped to a 123 Kb interval on chromosome 5 using molecular markers. All aspects of the knuckles phenotype could be complemented by a genomic fragment from the region which contained the annotated MAC12.2 gene. A guanine to adenine transition within a predicted C2H2 zinc finger-encoding region of MAC12.2 causes the second of two critical zinc-binding cysteine residues to be replaced by a tyrosine. Transgenic plants in which translational fusions of the GUS reporter to KNUCKLES were driven by the presumptive KNUCKLES promoter indicate that the gene is expressed first in developing carpel primordia, and later in stamens and ovules of flower buds. In situ hybridization experiments showed a broader pattern of transcript localization, suggesting that post-transcriptional regulatory mechanisms may limit KNUCKLES protein accumulation and localization. Based on genetic evidence and the presence of a carboxy-terminal motif demonstrated by others to function as an active repression domain, we propose that KNUCKLES might function as a transcri...Continue Reading

References

Mar 25, 1991·Nucleic Acids Research·K EdwardsC Thompson
Jan 15, 1988·Cell·R M Evans, S M Hollenberg
Jan 14, 1994·Cell·C Gustafson-BrownM F Yanofsky
May 1, 1995·Plant Molecular Biology·B W Tague, H M Goodman
Jul 1, 1994·Genes & Development·K Goto, E M Meyerowitz
Jan 7, 1998·Nature Biotechnology·G L RotinoA Spena
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
May 20, 1999·Current Topics in Developmental Biology·J L BowmanJ Alvarez
Oct 12, 1999·Plant Physiology·A Vivian-Smith, A M Koltunow
Dec 22, 1999·Genes & Development·J M VillanuevaC S Gasser
Mar 15, 2000·Nature·J P Vielle-CalzadaU Grossniklaus
Jun 29, 2000·Annual Review of Biochemistry·C FerrándizM F Yanofsky
Aug 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LuoA Chaudhury
Aug 3, 2002·Plant & Cell Physiology·Randy DinkinsGlenn B Collins

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Citations

Jan 1, 2010·The Arabidopsis Book·Elena R Alvarez-BuyllaYara E Sánchez-Corrales
Jan 1, 2006·The Arabidopsis Book·Adrienne H K Roeder, Martin F Yanofsky
Nov 22, 2007·Molecular Genetics and Genomics : MGG·Chang-Jie JiangHiroshi Takatsuji
Aug 5, 2009·Genes & Development·Feng Ming, Hong Ma
Mar 25, 2014·Planta·Mariana Sotelo-SilveiraStefan de Folter
May 28, 2014·Plant Physiology and Biochemistry : PPB·Qing-jie GuanZhen-yu Wang
Apr 10, 2014·Cellular and Molecular Life Sciences : CMLS·Julia EngelhornCristel C Carles
Sep 28, 2010·Current Opinion in Plant Biology·Toshiro Ito
Apr 16, 2008·The Plant Journal : for Cell and Molecular Biology·Adrien SicardMichel Hernould
Jul 21, 2011·The Plant Journal : for Cell and Molecular Biology·Magdalena WeingartnerNorbert Sauer
Sep 6, 2013·The Plant Journal : for Cell and Molecular Biology·Teresa Lenser, Günter Theißen
Apr 23, 2010·The Plant Journal : for Cell and Molecular Biology·Vivian F Irish
May 8, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Bhupinder Sehra, Robert G Franks
Oct 4, 2014·The Plant Journal : for Cell and Molecular Biology·Liza J ConradVenkatesan Sundaresan
Dec 15, 2010·Developmental Biology·Shinichiro YamakiKen-ichi Nonomura
Feb 24, 2015·Frontiers in Plant Science·Bo Sun, Toshiro Ito
Feb 7, 2015·PLoS Genetics·Encarnación Rodríguez-CazorlaAntonio Vera
Jun 27, 2018·Plant Signaling & Behavior·N BollierF Delmas
Feb 5, 2019·Journal of Experimental Botany·Victor M Zúñiga-MayoStefan de Folter
May 8, 2019·Journal of Experimental Botany·Jorge LoraMathew R Tucker
Dec 31, 2017·Proceedings of the National Academy of Sciences of the United States of America·Lihua ZhaoYuan Qin

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