Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Quadri Kunle AlabiAyowole A Oladele

Abstract

The beneficial effects of kolaviron, a natural biflavonoid from the seeds of Garcinia kola, have been attributed to its antioxidant and anti-inflammatory activities. This study was designed to investigate the renoprotective effect of kolaviron in rat model of diclofenac (DFC)-induced acute renal failure. Thirty-five male Wistar rats were divided into 7 groups of 5 rats each as follows: a control group that received propylene glycol orally and treatment groups that received DFC, DFC recovery, DFC followed by kolaviron at 3 different doses, and kolaviron only. DFC-treated rats showed sluggishness, illness, and anorexia. Their urine contained appreciable protein, glucose, and ketone bodies. Histopathological examination of their kidneys revealed profound acute tubular necrosis. DFC treatment significantly increased levels of plasma creatinine, urea, sodium, chloride, potassium ions, and increased renal tissue activities of superoxide dismutase, catalase, levels of malondialdehyde, and hydrogen peroxide. Fractional excretion of sodium and potassium and renal tissue levels of reduced glutathione and prostaglandin E2 (PGE2) decreased significantly in DFC-treated groups. However, kolaviron administration significantly reduced the toxi...Continue Reading

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Citations

Jul 25, 2019·Journal of Biochemical and Molecular Toxicology·Mojtaba ShakibaieHamid-Reza Rahimi
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aliyat O NafiuOluwole O Odujoko
Mar 26, 2021·Environmental Science and Pollution Research International·Adeoye Oyewole IdrisEzekiel Olugbenga Iwalewa
Nov 4, 2021·BMC Complementary Medicine and Therapies·Quadri K AlabiDeborah Kajewole-Alabi

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