Konzo and continuing cyanide intoxication from cassava in Mozambique

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J CliffJ Howard Bradbury

Abstract

In Mozambique, epidemics of the cassava-associated paralytic disease, konzo, have been reported in association with drought or war: over 1100 cases in 1981, over 600 cases in 1992-1993, and over 100 cases in 2005. Smaller epidemics and sporadic cases have also been reported. Large epidemics have occurred at times of agricultural crisis, during the cassava harvest, when the population has been dependent on a diet of insufficiently processed bitter cassava. Konzo mostly affects women of child-bearing age and children over 2 years of age. When measured, serum or urinary thiocyanate concentrations, indicative of cyanide poisoning, have been high in konzo patients during epidemics and in succeeding years. Monitoring of urinary thiocyanate concentrations in schoolchildren in konzo areas has shown persistently high concentrations at the time of the cassava harvest. Inorganic sulphate concentrations have been low during and soon after epidemics. Programmes to prevent konzo have focused on distributing less toxic varieties of cassava and disseminating new processing methods, such as grating and the flour wetting method. Attention should be given to the wider question of agricultural development and food security in the regions of Africa...Continue Reading

References

Feb 1, 1990·Brain : a Journal of Neurology·W P HowlettH Rosling
Aug 1, 1986·Journal of Tropical Pediatrics·J CliffH Rosling
Jun 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·P LundquistL Nilsson
Jun 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·T TylleskärH Rosling
Dec 10, 1997·Tropical Medicine & International Health : TM & IH·J CliffJ Howarth
Aug 26, 1998·International Journal of Food Sciences and Nutrition·A P CardosoJ H Bradbury
Jun 1, 2002·Acta Tropica·Mario ErnestoJ Howard Bradbury
Jun 30, 2004·International Journal of Food Sciences and Nutrition·A Paula CardosoJ Howard Bradbury

❮ Previous
Next ❯

Citations

Jul 9, 2011·PLoS Neglected Tropical Diseases·Hipólito Nzwalo, Julie Cliff
Feb 1, 2014·Metabolic Brain Disease·G M BumokoD D Tshala-Katumbay
Apr 4, 2013·Expert Review of Respiratory Medicine·Todd F HuzarJames M Cross
Sep 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N L V MlingiJ H Bradbury
Jun 1, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J Howard BradburyIan C Denton
Dec 20, 2014·Annals of Neurology·Olusegun Steven A Oluwole
Jan 17, 2015·Journal of the Neurological Sciences·G M-M BumokoD Tshala-Katumbay
Feb 7, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S KimaniD Tshala-Katumbay
Jul 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bola Adamolekun
Feb 22, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J P BaneaN Kuwa
Jul 28, 2016·Annals of the New York Academy of Sciences·Desire D Tshala-KatumbayJean-Pierre Banea
Apr 5, 2019·MMWR. Morbidity and Mortality Weekly Report·Phoebe H AlitubeeraBao-Ping Zhu
May 23, 2020·Public Health Nutrition·Jatziri Mota-Gutierrez, Gerard Michael O'Brien
May 15, 2020·Journal of Environmental and Public Health·Birungi DoreenBao-Ping Zhu
Jun 26, 2020·Journal of Experimental Botany·Mohammad Abass AhangerParvaiz Ahmad
Sep 23, 2019·Revue neurologique·V S PalmerP S Spencer
May 9, 2021·The American Journal of Clinical Nutrition·Merry C FitzpatrickDaniel G Maxwell
May 9, 2021·Neurotoxicology·Marius BagumaJoëlle Nsimire Chabwine
Sep 12, 2021·Nature Communications·Matthew S BrambleEric Vilain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
N L V MlingiJ Howard Bradbury
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J Howard BradburyIan C Denton
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J N ChabwineB Nemery
© 2021 Meta ULC. All rights reserved