PMID: 11323079Apr 27, 2001Paper

KO's and organisation of peptidergic feeding behavior mechanisms

Neuroscience and Biobehavioral Reviews
Bernard Beck

Abstract

Feeding behavior results from complex interactions arising between numerous neuromediators, including classical neurotransmitters and neuropeptides present in hypothalamic networks. One way to unravel these complex mechanisms is to examine animal models with a deletion of genes coding for the different neuropeptides involved in the regulation of feeding. The aim of this review is to focus on feeding and body weight regulation in mice lacking neuropeptide Y (NPY), melanocortins (POMC), corticotropin-releasing hormone, melanin-concentrating hormone, or bombesin-like peptides respectively. The phenotypes, which relate to the deletion of gene coding for the peptides, rarely include changes in body weight and food intake, indicating therefore the existence of redundant mechanisms to compensate for the loss of the peptide. The phenotype is much more marked when the gene deletion is targeted towards the functioning of the peptidergic machinery, e.g. the receptors and especially the POMC and NPY receptors, as well as one subtype of bombesin receptor (BRS-3). These knockout models are also interesting when examining the role of environmental and social factors in the determination of feeding behavior. They have granted us better knowled...Continue Reading

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Citations

Oct 14, 2008·Genes & Nutrition·Alessandro BartolomucciAnna Moles
May 28, 2005·Biochemical and Biophysical Research Communications·Bernard BeckAlain Stricker-Krongrad
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