Kowalski ester homologation. application to the synthesis of beta-amino esters

The Journal of Organic Chemistry
Diane GrayTimothy Gallagher

Abstract

The Kowalski ester homologation protocol has been applied to a representative range of alpha-amino esters to provide beta-amino esters with excellent levels of enantio- and diastereocontrol. A key feature of this chemistry is the nature of the N-protecting group that is employed.

References

Nov 17, 2001·Chemical Reviews·R P ChengW F DeGrado
Dec 16, 2003·Angewandte Chemie·Norbert Sewald

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Citations

Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Konstantin V Kudryavtsev, Veronika V Irkha
Jul 30, 2014·Organic Letters·Joanna WlochalJonathan Burton
Jul 30, 2015·Organic & Biomolecular Chemistry·Manas K GhoraiAmit Kumar
Aug 1, 2018·Archiv der Pharmazie·Linda KinenaAigars Jirgensons
Apr 12, 2008·Angewandte Chemie·Christopher M ByrneGeoffrey W Coates
Mar 1, 2017·Chemical Communications : Chem Comm·Benjamin J HaugebergMichael D Clift
Aug 16, 2012·Organic Letters·Tommaso AngeliniLuigi Vaccaro
Jan 15, 2014·The Journal of Organic Chemistry·Basker RajagopalPo-Chiao Lin
May 12, 2005·Journal of the American Chemical Society·Damien BonneJieping Zhu

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