Kramecyne--a new anti-inflammatory compound isolated from Krameria cytisoides.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Salud Pérez-GutiérrezCuauhtemoc Pérez-González

Abstract

In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.

Citations

Jun 26, 2015·Drug Development Research·Angel Josabad Alonso-CastroSalud Pérez-Gutiérrez
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·E Sánchez-MirandaJ Pérez-Ramos
Dec 6, 2014·Life Sciences·Angel Josabad Alonso-CastroSalud Pérez-Gutiérrez
Feb 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Leticia Eligio-GarcíaEnedina Jiménez-Cardoso

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Methods Mentioned

BETA
NMR
acetylation

Software Mentioned

ACD Labs

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