KRAS -associated microRNAs in colorectal cancer

Oncology Reviews
Hamizah Ibrahim, Ya Chee Lim

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancerrelated death worldwide. Despite progress in treatment of cancers, CRC with KRAS mutations are resistant towards anti-EGFR treatment. MicroRNAs have been discovered in an exponential manner within the last few years and have been known to exert either an onco-miRNA or tumor suppressive effect. Here, the various roles of microRNAs involved in the initiation and progression of KRAS-regulated CRC are summarized. A thorough understanding of the roles and functions of the plethora of microRNAs associated with KRAS in CRC will grant insights into the provision of other potential therapeutic targets as well as treatment. MicroRNAs may also serve as potential molecular classifier or early detection biomarkers for future treatment and diagnosis of CRC.

References

May 3, 2006·Biological & Pharmaceutical Bulletin·Yukihiro AkaoTomoki Naoe
Jan 13, 2009·Oncogene·X ChenC-Y Zhang
Apr 18, 2009·Carcinogenesis·Wing Pui Tsang, Tim Tak Kwok
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marilena V Iorio, Carlo M Croce
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Sylwia JancíkMarián Hajdúch
Dec 3, 2010·The Journal of Pathology·Efsevia Vakiani, David B Solit
Jan 27, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Man-Li YuYong-Wen Qin
Jul 23, 2011·Genes & Cancer·Alberto Fernández-Medarde, Eugenio Santos
Sep 17, 2011·Genes, Chromosomes & Cancer·Neda MosakhaniSakari Knuutila
Oct 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kim M SmitsManon van Engeland
May 17, 2012·Cancer Research·Ian A PriorCarla Mattos
Jun 1, 2012·The Cancer Journal·Aaron J SchetterCurtis C Harris
Jun 5, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhao-Hui LiLin-Bo Gao
Jun 27, 2013·World Journal of Gastrointestinal Oncology·Kypros Zenonos, Katy Kyprianou
Aug 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin-Min PanLin-Bo Gao
Oct 1, 2013·Journal of Clinical Bioinformatics·Gadareth Higgs, Frank Slack
Dec 26, 2013·Oncotarget·Florian KoppAndreas Roidl
Jan 8, 2014·Mayo Clinic Proceedings·Dennis J AhnenY Nancy You
Apr 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gilles ManceauPierre Laurent-Puig
Sep 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zenia SaridakiSabine Tejpar
Sep 23, 2014·International Journal of Molecular Medicine·Xuan HuangDa-Lin Lu
Oct 8, 2014·Journal of Biomedical Science·Kong Bung ChooChiu-Jung Huang
Dec 1, 2014·Journal of Hematology & Oncology·Minlee Kim, Frank J Slack
Dec 5, 2014·Annals of Surgical Oncology·Akira InoueMasaki Mori
Dec 6, 2014·Contemporary Oncology Współczesna Onkologia·Tomasz KolendaKatarzyna M Lamperska
Dec 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhong-chuan LvDa-wei Zhao
Mar 11, 2015·Molecular Therapy. Nucleic Acids·Masayuki HirakiHirofumi Yamamoto
May 23, 2015·Nature Reviews. Cancer·Shuibin Lin, Richard I Gregory

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Citations

Sep 23, 2021·Biotechnology and Applied Biochemistry·Sahand MoazzendizajiHamed Mohammadi

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Methods Mentioned

BETA
GTPases
GTPase
transfection
xenograft
xenografts
Assay

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