KRAS Activating Signaling Triggers Arteriovenous Malformations

Trends in Biochemical Sciences
Feixiong Cheng, Ruth Nussinov

Abstract

The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.

Citations

Jun 28, 2019·Current Opinion in Pediatrics·Miguel Zúñiga-CastilloJoyce M C Teng
Dec 14, 2018·Pharmacological Reviews·Feixiong ChengRuth Nussinov
Feb 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruth NussinovHyunbum Jang
Jan 6, 2019·Biophysics Reviews·Ruth NussinovFeixiong Cheng

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