Abstract
Pulmonary sarcomatoid carcinoma (PSC) is a poorly differentiated non-small-cell lung carcinoma (NSCLC) with aggressive behaviour. This study aimed to evaluate the prognostic clinicopathological and genetic characteristics of PSCs. Fifty-three cases of surgically treated PSCs were selected, 23 of which were subjected to mutation and copy number variation analysis using the 50-gene Ion AmpliSeq Cancer Panel. The majority of the patients were male (32 of 53, 60.3%) and smokers (51 of 53, 96.2%). Overall, 25 (47.1%) patients died within 2-105 months (mean = 22.7 months, median = 15 months) after diagnosis, and 28 were alive 3-141 months (mean = 38.7 months, median = 21.5 months) after diagnosis. Five-year overall survival was 12.5%. KRAS codon 12/13 mutation in adenocarcinomas (P = 0.01), age more than 70 years (P = 0.008) and tumour size ≥4.0 cm (P = 0.02) were associated strongly with worse outcome. TP53 (17 of 23, 74.0%) and KRAS codon 12 of 13 mutations (10 of 23, 43.4%) were the most common genetic alterations. Potentially actionable variants were identified including ATM (four of 23, 17.3%), MET, FBXW7 and EGFR (two of 23, 8.7%), AKT1, KIT, PDGFRA, HRAS, JAK3 and SMAD4 (one of 23, 4.3%). MET exon 14 skipping and missense muta...Continue Reading
References
Aug 30, 1990·The New England Journal of Medicine·R J SlebosW J Mooi
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming-Sound TsaoFrances A Shepherd
Jan 22, 2009·Japanese Journal of Clinical Oncology·Atsuhito UshikiJun Nakayama
Jun 30, 2009·Nature Protocols·Prateek KumarPauline C Ng
Aug 15, 2009·International Journal of Cancer. Journal International Du Cancer·Antoine ItalianoFlorence Pedeutour
Apr 1, 2010·Nature Methods·Ivan A AdzhubeiShamil R Sunyaev
Jul 6, 2010·Nucleic Acids Research·Kai WangHakon Hakonarson
Mar 17, 2011·Annals of Surgical Oncology·Yih-Leong ChangYung-Chie Lee
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Jun 29, 2012·Surgery·Sai YendamuriMary Reid
Jul 20, 2012·Cancer·Melissa L JohnsonGregory J Riely
Mar 26, 2013·Cancer·Liza C VillaruzSanja Dacic
Apr 5, 2013·Archives of Pathology & Laboratory Medicine·Neal I LindemanMarc Ladanyi
Feb 12, 2014·American Journal of Clinical Pathology·Zaibo LiSara E Monaco
Jul 6, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thibault VieiraMarie Wislez
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 3, 2014·Bioinformatics·Reece K HartVincent A Fusaro
Nov 22, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Helena A YuGregory J Riely
Feb 24, 2015·Bioinformatics·Adrian TanHyun Min Kang
May 15, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V FalletM Wislez
May 15, 2015·Cancer Discovery·Garrett M FramptonVincent A Miller
May 15, 2015·Cancer Discovery·Paul K PaikMarc Ladanyi
Jul 3, 2015·Oncology Letters·Fangwen ZouJiao-Yun Zheng
Jul 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xuewen LiuAlain C Borczuk
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson
Dec 29, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Carrie LeeJared Weiss
Jan 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark M AwadLynette M Sholl
Apr 16, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Frank SchneiderSanja Dacic
Apr 23, 2016·PLoS Computational Biology·Eric TalevichBoris C Bastian
Apr 24, 2016·Clinical Lung Cancer·Mony UngJulien Mazières
May 10, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Filippo LococoAlessia Ciarrocchi
May 14, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simone Bsp TerraJennifer M Boland
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexa B SchrockSai-Hong Ignatius Ou
Oct 22, 2016·Oncotarget·Sanja DacicMarina N Nikiforova
Dec 21, 2016·The Journal of Molecular Diagnostics : JMD·Marilyn M LiMarina N Nikiforova
Mar 21, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexa B SchrockJane J Liu
Citations
Mar 26, 2019·Diagnostic Cytopathology·Atreyee BasuTamar C Brandler
Jun 6, 2019·Annals of Nuclear Medicine·Xiaodong WuLei Jiang
Jul 13, 2019·Free Radical Research·Qianlei YangYan An
Sep 29, 2020·Nature Communications·Zhenlin YangJie He
Sep 15, 2020·Therapeutic Advances in Medical Oncology·Xin LiJun Chen
Jun 19, 2019·BMC Cancer·Jianjun GeJun Chen
Jun 6, 2020·Medicine·Feng-Wei KongMiao Zhang
Dec 5, 2020·Oncogene·Xuewen LiuLikun Chen
Mar 9, 2021·The Journal of Thoracic and Cardiovascular Surgery·Hussein M AbdallahOlugbenga T Okusanya
Dec 10, 2021·Future Oncology·Yue ZhengYu Zhang