Kras, Pten, NF-κB, and inflammation: dangerous liaisons

Cancer Discovery
Paul J Chiao, Jianhua Ling

Abstract

Ying and colleagues identify a novel function of Pten as a haploinsufficient tumor suppressor in human pancreatic cancer development. Genomic, genetic, and biochemical data reveal that Pten loss and Kras mutation cooperate to accelerate pancreatic cancer development by altering PI3K regulation to enhance NF-κB activation and upregulate downstream cytokine genes; this provides a protumorigenic and metastatic microenvironment.

References

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Citations

Apr 9, 2013·Future Oncology·Min ZhengXin-hua Liang
May 6, 2016·Biomarkers in Cancer·Fataneh Karandish, Sanku Mallik
Jul 14, 2017·Journal of Cellular Biochemistry·Matineh Barati BagherabadAmir Avan
Aug 29, 2019·Cell Reports·Nilanjana ChatterjeeTrever G Bivona

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