KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

doi:10.3390/ijms20194930

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

International Journal of Molecular Sciences

Oct 5, 2019

Francesco Vieceli Dalla SegaSaverio Francesco Retta

PMID: 31590384

DOI: 10.3390/ijms20194930

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Abstract

Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the ...read more

Mentioned in this Paper

Tissue Adhesions

Aorta

Aortic Arch Structure

Atherosclerosis

Blood Vessel

Blood Capillaries

Cell Adhesion Molecules

Cerebrovascular Disorders

Diet

Disease Susceptibility

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