KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

doi:10.3390/ijms20194930

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

International Journal of Molecular Sciences

Oct 9, 2019

Francesco Vieceli Dalla SegaSaverio Francesco Retta

PMID: 31590384

DOI: 10.3390/ijms20194930

Abstract

Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the ...read more

Mentioned in this Paper

Study

Endothelial Cell-cell Adhesion

Diet

Pathogenesis

Tumor Necrosis Factor-alpha

VCAM1

Genes

KRIT1 protein, human

Blood Vessel

Cerebral Cavernous Malformations 1

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