journal cover

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

Free Radical Biology & Medicine

Nov 25, 2017

Cinzia AntognelliSaverio Francesco Retta

Abstract

KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3-0.5% of the population. Previously, we demonstrated that KRIT1 loss-of-function is associated with altered redox homeostasis and ...read more

Mentioned in this Paper

GABPA gene
GLO1 gene
HSPA4 gene
NFE2L2 gene
Post-Translational Regulation
Genetic Translation Process
Metabolic Process, Cellular
Recombinant 70-kD Heat-Shock Protein
KRIT1 gene
Chronic Kidney Diseases
2
18

Similar Papers Found In These Feeds

Cerebrovascular Disease

Cerebrovascular disease is an important cause of cognitive impairment and dementia in elderly patients. Discover the latest research on cerebrovascular disease here.

Chaperones & Protein Folding

Chaperones are proteins that play an essential role in protein folding, stability, assembly, and degradation. Their depletion or dysfunction has been implicated in protein folding disorders. Here is the latest research.

PTMs of Transcription Factors (Keystone)

This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.

PARP Inhibitors

PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.

DNA Damage

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic stability. Here is the latest research pertaining to DNA damage.

PTMs of Transcription Factors

This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

Neuromuscular Junction Diseases

Diseases of the neuromuscular junction cause skeletal muscle fatigue and include inherited and acquired disorders that affect presynaptic, intrasynaptic or postsynaptic components. Discover the latest research on neuromuscular junction diseases here.

Nrf2 Signaling in Inflammation

Nrf2 facilitates the recruitment of inflammatory cells, regulates expression of anti-inflammatory genes through the antioxidant response element, and plays a role in regulation of the inflammasome. Here is the latest research on Nrf2 signaling in inflammation.

Poly(ADP-Ribose) Polymerases

Poly(ADP-Ribose) Polymerase (PARP) is an enzyme with several functions, including cell differentiation, proliferation, and DNA damage repair. Here is the latest research on PARP.

© 2020 Meta ULC. All rights reserved

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

Free Radical Biology & Medicine

Nov 25, 2017

Cinzia AntognelliSaverio Francesco Retta

PMID: 29170092

DOI: 10.1016/j.freeradbiomed.2017.11.014

Abstract

KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3-0.5% of the population. Previously, we demonstrated that KRIT1 loss-of-function is associated with altered redox homeostasis and ...read more

Mentioned in this Paper

GABPA gene
GLO1 gene
HSPA4 gene
NFE2L2 gene
Post-Translational Regulation
Genetic Translation Process
Metabolic Process, Cellular
Recombinant 70-kD Heat-Shock Protein
KRIT1 gene
Chronic Kidney Diseases
2
18

Similar Papers Found In These Feeds

Related Papers

/papers/krit1-loss-of-function-induces-a-chronic-nrf2-medi/29170092