Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats.

Frontiers in Pharmacology
Zuqing SuYing Zhu

Abstract

Background: Metabolic syndrome is characterized by central obesity, hyperglycemia and hyperlipidemia. Insulin resistance is the leading risk factor for metabolic syndrome. Kun-Dan decoction (KD), a traditional Chinese medicine, has been applied to treat patients with metabolic syndrome for over ten years. It is increasingly recognized that autophagy deficiency is the key cause of metabolic syndrome. Therefore, we aimed to explore whether KD can activate autophagy to improve metabolic syndrome. Methods: Network pharmacology was used to explore the underlying mechanism of KD in the treatment of metabolic syndrome. The high-fat diet-fed rats and oleic acid-induced LO2 cells were employed in our study. Oral glucose tolerance test and insulin tolerance test, obesity and histological examination, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity in high-fat diet-fed rats were analyzed. Furthermore, the protein expressions of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), phospho-AMPK, mammalian target of rapamycin (mTOR), phospho-mTOR, p62, autophagy related ...Continue Reading

References

Nov 5, 2005·Circulation Research·Chikaaki KobashiMasashi Kobayashi
Feb 15, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F LeiL J Du
Jun 9, 2009·Clinical Biochemistry·Reza Meshkani, Khosrow Adeli
Dec 30, 2009·The Journal of Clinical Investigation·Marie-Therese RachedStavroula Kousteni
Feb 11, 2010·Cell·Noboru MizushimaBeth Levine
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Jun 22, 2013·Chinese Journal of Natural Medicines·Shao Li, Bo Zhang
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Huiying LiXiaolin Tong
Jul 19, 2014·The Journal of Clinical Investigation·Jinyoung KimMyung-Shik Lee
Sep 19, 2014·Molecular Medicine Reports·Shi-Wei ZhouMin Zhu
Jan 28, 2015·Molecular and Cellular Biology·Katsuya NagaokaMitsuyoshi Nakao
Jul 18, 2015·Journal of Diabetes Research·Christian Ferdinand JurowichHermann Koepsell
Sep 27, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Hadi KhodabandehlooReza Meshkani
Nov 14, 2017·Autophagy·Alexandra C RacanelliSuzanne M Cloonan
Feb 23, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ying Pan, Ling-Dong Kong
Feb 28, 2018·Current Medicinal Chemistry·Silvia Cerri, Fabio Blandini
Mar 16, 2018·Metabolic Brain Disease·Karolina PierzynowskaGrzegorz Węgrzyn
Apr 14, 2018·Nature Communications·Hyejin LimMyung-Shik Lee
Nov 22, 2018·Trends in Pharmacological Sciences·Jun Ren, Yingmei Zhang
Nov 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoqin DingJian Chen
Jan 31, 2019·World Journal of Diabetes·Daniella Lent-SchochetIshwarlal Jialal
Jun 27, 2019·Diabetes & Metabolic Syndrome·Endy AdnanH P Faridin
Jul 28, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Wan-Chin KuoRoger L Brown
Sep 3, 2019·Frontiers in Endocrinology·Vardit Gepstein, Ram Weiss
Oct 28, 2019·Frontiers in Pharmacology·Zuqing SuGuangjuan Zheng

❮ Previous
Next ❯

Software Mentioned

R
SPSS
Image Pro plus
Cytoscape
Bioconductor
CytoNCA

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms