PMID: 9161848Mar 1, 1997Paper

Kupffer cell function in thyroid hormone-induced liver oxidative stress in the rat

Free Radical Research
Gladys TapiaL A Videla

Abstract

The influence of thyroid hormone (L-3, 3', 5-triiodothyronine, T3) on Kupffer cell function was studied in the isolated perfused rat liver by colloidal carbon infusion. Rates of carbon uptake were determined from the influent minus effluent concentration difference and the flow rate, and the respective carbon-induced respiratory activity was calculated by integration of the area under the O2 curves during carbon infusion. In the concentration range of 0.2 to 2.0 mg of carbon/ml, livers from euthyroid rats exhibited a sigmoidal-type kinetics of carbon uptake, with a Vmax of 4.8 mg/g liver/min and a concentration of 0.82 mg/ml for half-maximal rate; carbon-induced O2 uptake presented a hyperbolic-type kinetics, with a Vmax of 4.57 mumol of O2/g liver and a K(m) of 0.74 mg of carbon/ml, which significantly correlates with the carbon uptake rates. Light-microscopy showed that carbon was taken up exclusively by non-parenchymal cells, predominantly by Kupffer cells. Thyroid calorigenesis was found in parallel with increased rates of hepatic O2 consumption and thiobarbituric acid reactive substances (TBARS) formation, glutathione (GSH) depletion, and higher sinusoidal lactate dehydrogenase (LDH) efflux compared to control values. In t...Continue Reading

References

Feb 1, 1991·The American Journal of Physiology·A K WilsonP De Lanerolle
Sep 11, 1990·European Journal of Biochemistry·K Decker
Jan 1, 1989·International Review of Cytology·K WakeE Wisse
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
Jan 1, 1988·Free Radical Research Communications·V FernandezA Boveris
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BouwensE Wisse
May 15, 1985·Experientia·L C Triarhou, M del Cerro
Sep 1, 1981·European Journal of Biochemistry·R BhatnagarK Decker
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P Nolan
Mar 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A I MarzoevIu A Vladimirov
Nov 9, 1995·Biochemical Pharmacology·L A VidelaV Fernández
Jul 1, 1993·Archives of Biochemistry and Biophysics·J F WangH de Groot
Jan 1, 1993·Research in Developmental Disabilities·M D SaundersR R Saunders

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Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G TapiaL A Videla
Mar 31, 2012·Journal of Molecular Histology·Bárbara NúñezLuis A Videla
May 14, 2011·Thyroid : Official Journal of the American Thyroid Association·Pamela RomanqueLuis A Videla
Feb 7, 2008·Comparative Hepatology·Maria-Angeles AllerJorge-Luis Arias
Jul 28, 2007·Biological Chemistry·Virginia FernándezLuis A Videla
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Jul 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L A VidelaV B Junqueira
Mar 23, 2010·Molecular and Cellular Endocrinology·G TapiaV Fernández
Oct 6, 2015·Free Radical Biology & Medicine·Luis A VidelaNelson Varela
Aug 5, 2008·Critical Reviews in Oncology/hematology·Manuela Gago-Dominguez, Jose Esteban Castelao
Jul 26, 2008·European Journal of Pharmacology·Adriana Salazar-MontesJuan Armendáriz-Borunda
Mar 1, 2008·Medical Hypotheses·J Esteban Castelao, Manuela Gago-Dominguez
Mar 31, 2004·Molecular Aspects of Medicine·Ligia F GomesLuis A Videla
Apr 25, 2006·Free Radical Biology & Medicine·Gladys TapiaLuis A Videla
Nov 22, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Virginia FernándezLuis A Videla
Feb 26, 2004·Redox Report : Communications in Free Radical Research·Pamela RomanqueLuis A Videla
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Mar 24, 2000·Redox Report : Communications in Free Radical Research·X BoisierL A Videla
May 26, 2015·Expert Reviews in Molecular Medicine·Luis A VidelaIván Castillo
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·V FernándezL A Videla
Nov 18, 2016·The Journal of Endocrinology·Anne H van der SpekAnita Boelen
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Virginia FernándezLuis A Videla
Dec 8, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Felipe A CisternasMagdalena Araya
Oct 31, 2009·World Journal of Hepatology·Luis A Videla

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