PMID: 2499535Jan 1, 1989Paper

Kupffer cells and the acute phase response: the effect of aging

Immunological Investigations
D L Knook, A Brouwer

Abstract

Aging is associated with a significant increase in the susceptibility to scepsis and endotoxin induced shock in both man and experimental animals. In this study, some metabolic, heamodynamic and other pathophysiological factors possibly involved in the increased mortality of aged rats after endotoxin administration were investigated. The results indicate that older rats display an overall decrease in the capacity to maintain homeostasis after endotoxin challenge, which is expressed by severe disregulation of body temperature (hypothermia), glucose metabolism (hypoglycemia), tissue perfusion (fibrinolytic and anti-fibrinolytic factors) and severe tissue damage. Although a slight decrease in the clearance of endotoxin from the circulation was noted in old rats, alterations in the secondary response, evoked by stimulated macrophages and other cells appear to be more important in the age-related increase in susceptibility.

References

Sep 1, 1987·Journal of Gerontology·W Schumer, R E Kuttner
Jan 1, 1988·Reviews of Infectious Diseases·E HatziandreuM A Stoto
Dec 1, 1986·Archives of Gerontology and Geriatrics·A BrouwerD L Knook
Aug 26, 1986·Nucleic Acids Research·S M Heywood
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A BrouwerD L Knook
Mar 1, 1983·Mechanisms of Ageing and Development·A Brouwer, D L Knook

❮ Previous
Next ❯

Citations

Nov 1, 1990·Journal of Hepatology·A BrouwerD L Knook
Nov 7, 2019·Histochemistry and Cell Biology·Steven A BloomerKevin C Kregel
Jan 31, 2002·World Journal of Gastroenterology : WJG·Wen-Bing SunRui-Liang Ma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Anti-infective Therapy
François BaillyChristian Trepo
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
M WardasB Radwańska-Wala
© 2022 Meta ULC. All rights reserved