Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Vahagn OhanyanWilliam M Chilian

Abstract

The connection between metabolism and flow in the heart, metabolic dilation, is essential for cardiac function. We recently found redox-sensitive Kv1.5 channels play a role in coronary metabolic dilation; however, more than one ion channel likely plays a role in this process as animals null for these channels still showed limited coronary metabolic dilation. Accordingly, we examined the role of another Kv1 family channel, the energetically linked Kv1.3 channel, in coronary metabolic dilation. We measured myocardial blood flow (contrast echocardiography) during norepinephrine-induced increases in cardiac work (heart rate x mean arterial pressure) in WT, WT mice given correolide (preferential Kv1.3 antagonist), and Kv1.3-null mice (Kv1.3-/- ). We also measured relaxation of isolated small arteries mounted in a myograph. During increased cardiac work, myocardial blood flow was attenuated in Kv1.3-/- and in correolide-treated mice. In isolated vessels from Kv1.3-/- mice, relaxation to H2 O2 was impaired (vs WT), but responses to adenosine and acetylcholine were equivalent to WT. Correolide reduced dilation to adenosine and acetylcholine in WT and Kv1.3-/- , but had no effect on H2 O2 -dependent dilation in vessels from Kv1.3-/- mic...Continue Reading

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Citations

Jul 23, 2019·Clinical and Experimental Pharmacology & Physiology·Hongliang LiWon Sun Park
Jan 12, 2020·Cardiovascular Research·Oana SoropDirk J Duncker
May 6, 2020·International Journal of Molecular Sciences·Paolo SeverinoFrancesco Fedele
Nov 8, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Marc M DwengerMatthew A Nystoriak
Oct 7, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·William F Jackson
Jun 21, 2020·European Journal of Pharmacology·Vladimir DjokicLjiljana Gojkovic-Bukarica
Jan 28, 2021·Circulation Research·Vahagn OhanyanMatthew A Nystoriak
May 2, 2021·Medicinal Research Reviews·Špela GubičLucija P Mašič

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