KV7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine

American Journal of Physiology. Heart and Circulatory Physiology
Adam G GoodwillGregory M Dick

Abstract

Hydrogen peroxide (H2O2) and voltage-dependent K(+) (KV) channels play key roles in regulating coronary blood flow in response to metabolic, ischemic, and paracrine stimuli. The KV channels responsible have not been identified, but KV7 channels are possible candidates. Existing data regarding KV7 channel function in the coronary circulation (limited to ex vivo assessments) are mixed. Thus we examined the hypothesis that KV7 channels are present in cells of the coronary vascular wall and regulate vasodilation in swine. We performed a variety of molecular, biochemical, and functional (in vivo and ex vivo) studies. Coronary arteries expressed KCNQ genes (quantitative PCR) and KV7.4 protein (Western blot). Immunostaining demonstrated KV7.4 expression in conduit and resistance vessels, perhaps most prominently in the endothelial and adventitial layers. Flupirtine, a KV7 opener, relaxed coronary artery rings, and this was attenuated by linopirdine, a KV7 blocker. Endothelial denudation inhibited the flupirtine-induced and linopirdine-sensitive relaxation of coronary artery rings. Moreover, linopirdine diminished bradykinin-induced endothelial-dependent relaxation of coronary artery rings. There was no effect of intracoronary flupirti...Continue Reading

References

Oct 1, 1986·The American Journal of Physiology·W M ChilianM L Marcus
Oct 29, 2000·Journal of Applied Physiology·M W GormanE O Feigl
Feb 8, 2003·Circulation Research·Hiroto MiuraDavid D Gutterman
Jul 19, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kenneth A SchenkmanEric O Feigl
Jul 19, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daniel A BeardEric O Feigl
Feb 1, 1963·The American Journal of Physiology·R M BERNE
Aug 2, 2005·British Journal of Pharmacology·Shuk Yin M Yeung, Iain A Greenwood
Jun 6, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Paul A RogersWilliam M Chilian
Oct 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Shu-ichi SaitohWilliam M Chilian
Oct 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Paul A RogersGregory M Dick
Sep 25, 2007·Journal of the American College of Cardiology·Toyotaka YadaFumihiko Kajiya
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Gregory M DickJohnathan D Tune
Jun 10, 2008·British Journal of Pharmacology·Sym YeungIa Greenwood
Jan 20, 2009·The Journal of Pharmacology and Experimental Therapeutics·Shreena JoshiAlison M Gurney
Apr 25, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas A JeppsSusumu Ohya
Feb 6, 2010·Journal of Cellular and Molecular Medicine·Laura A McCallumRachel M Tribe
Jul 14, 2010·The Journal of Physiology·Xi Zoë ZhongIain A Greenwood
Sep 16, 2010·British Journal of Pharmacology·Fu Liang NgIain A Greenwood
Jul 21, 2011·Journal of Molecular and Cellular Cardiology·Zachary C BerwickJohnathan D Tune
Oct 4, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lioubov I BrueggemannKenneth L Byron
Dec 14, 2011·The Journal of Physiology·John E LinleyNikita Gamper
May 18, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuo KansuiTakanari Kitazono
Aug 8, 2012·Antioxidants & Redox Signaling·Joseph R BurgoynePhilip Eaton
Nov 28, 2012·Hypertension·Olga ZavaritskayaRudolf Schubert
May 28, 2013·European Journal of Pharmacology·Julie SvaløPierre Bouchelouche
Jul 16, 2013·Methods in Enzymology·Christine C Winterbourn
Jul 17, 2013·Basic Research in Cardiology·Zachary C BerwickJohnathan D Tune
Oct 2, 2013·Hypertension·Saereh KhanamiriSøren-Peter Olesen
Oct 12, 2013·British Journal of Pharmacology·E R HedegaardU Simonsen
Dec 4, 2013·The Journal of Biological Chemistry·Lioubov I BrueggemannKenneth L Byron
Feb 22, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Preet S ChadhaIain A Greenwood
May 24, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna OliverasAntonio Felipe
Dec 6, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sewon LeeMichael A Hill
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jennifer B StottIain A Greenwood
Aug 1, 2015·Circulation Research·Vahagn OhanyanWilliam M Chilian

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Citations

Oct 26, 2010·Progress in Lipid Research·Anca D DobrianJerry L Nadler
Aug 9, 2016·Basic Research in Cardiology·Adam G GoodwillGregory M Dick
Apr 28, 2018·Clinical and Experimental Pharmacology & Physiology·Sean P NassoiyMatthias Majetschak
Oct 30, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jennifer B StottIain A Greenwood
Dec 7, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Maik GollaschRudolf Schubert
Oct 2, 2017·Basic Research in Cardiology·Alexander M KielJohnathan D Tune
Jul 18, 2020·Frontiers in Physiology·Gema Mondejar-ParreñoAngel Cogolludo

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