PMID: 11924719Apr 2, 2002Paper

Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Ken-ichi MizutaniN Iwai

Abstract

The rostral ventrolateral medulla (RVLM) plays a critical role in the tonic and reflexive regulation of arterial blood pressure. Recent studies have demonstrated that injection of kynurenic acid (KYN) into the RVLM of spontaneously hypertensive rats (SHR) decreases arterial blood pressure. We hypothesized that a relative increase in the excitatory amino acid-mediated drive of RVLM vasomotor neurons in SHR may be due to derangement of one of the enzymes that affect the KYN level in the brain. We selected kynureninase, kynureninase hydroxylase, kynurenine aminotransferase type I, and kynurenine aminotransferase type II as candidates that may affect the KYN level in the brainstem. We conducted association studies between polymorphisms of these genes and blood pressure in an F2 population derived from SHR and Wistar-Kyoto rats (WKY). The cosegregation analysis indicated that only the kynureninase gene (KYNU) polymorphism influenced systolic blood pressure (SBP) and residuals of systolic blood pressure after adjusting for heart rate and body weight (RSBP). KYNU was found to be located on rat chromosome 3, and quantitative trait loci analysis at this locus indicated that the logarithms of the odds scores for KYNU in terms of SBP and ...Continue Reading

References

Mar 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T KatsuyaT Ogihara
Mar 1, 1996·Hypertension·N IwaiM Kinoshita
Mar 1, 1996·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S TakamiT Ogihara
May 12, 1997·FEBS Letters·S TomaL Benatti
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

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Citations

Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciClara D Bloomfield
Mar 10, 2009·Journal of the Neurological Sciences·Eniko VamosLaszlo Vecsei
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Sep 15, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuki AkiraTakao Hashimoto
Sep 14, 2004·Journal of Human Hypertension·M O M Tanira, K A Al Balushi
Mar 21, 2017·Cellular and Molecular Life Sciences : CMLS·Ping SongMing-Hui Zou
Aug 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Cong HanZhen-Qiang Qi
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Carolyn J CrandallJanet Sinsheimer
Dec 21, 2004·European Journal of Biochemistry·Qian HanJianyong Li
Apr 9, 2021·Pharmacology & Therapeutics·Marta Marszalek-GrabskaWaldemar A Turski

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