Kynurenine and its metabolites in Alzheimer's disease patients

Advances in Medical Sciences
E GulajD Pawlak

Abstract

The kynurenine pathway (KP) is a major route of tryptophan metabolism. Several metabolites of this pathway are proposed to be involved in the pathogenesis of Alzheimer's disease. The aim of this study was to evaluate peripheral KP in patients with Alzheimer type dementia and a detailed analysis of correlation between kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), anthranilic acid (AA), quinolinic acid (QUIN) and degree of neuropsychological changes in AD. The plasma concentration of tryptophan and its products degradation by kynurenine pathway were analyzed in 34 patients suffering from Alzheimer type dementia and 18 controls in similar age using high-performance liquid chromatography technique. In demented patients we found lower tryptophan and KYNA concentrations. There was a non-significant increase of KYN, 3-HK and AA levels, and a Marked increase of QUIN in Alzheimer's disease group. We observed positive correlations between cognitive function tests and plasma KYNA levels, and inversely correlations between these tests and QUIN levels in Alzheimer type dementia. Increased TRP degradation and simultaneous altered kynurenines levels were found in plasma of AD patients. It proves activation of peripheral...Continue Reading

References

Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Sep 1, 1992·Neurology·T OgawaS Saso
Nov 1, 1990·Neurochemical Research·C L Eastman, T R Guilarte
Jul 11, 1989·Biochimica Et Biophysica Acta·G Werner-FelmayerH Wachter
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Nov 14, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L A PembertonB J Brew
May 5, 1999·Journal of Neural Transmission·H BaranL Deecke
May 23, 2000·Journal of Neural Transmission·B WidnerD Fuchs
Mar 20, 2002·Neurochemistry International·Rejane G TavaresDiogo O Souza
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Trevor W StoneL Gail Darlington
Jul 13, 2005·Neuropathology and Applied Neurobiology·G J GuilleminK M Cullen
Oct 7, 2006·Neurochemistry International·Zsuzsanna HartaiJános Kálmán
Jun 16, 2009·Neurotoxicity Research·Nady BraidyGilles J Guillemin
Jul 23, 2009·PloS One·Abdur RahmanGilles J Guillemin
Dec 17, 2009·Journal of Neuroinflammation·Ka Ka TingGilles J Guillemin

❮ Previous
Next ❯

Citations

Feb 18, 2011·Journal of Neuroinflammation·Allison B GoldKrista L Lanctôt
Apr 22, 2014·Cellular and Molecular Neurobiology·Peter VerstraelenJean-Pierre Timmermans
Jul 6, 2014·Journal of Pharmaceutical and Biomedical Analysis·R González-DomínguezJ L Gómez-Ariza
May 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marta AmaralFlaviano Giorgini
Jul 23, 2013·Trends in Molecular Medicine·Meng-Shan TanLan Tan
Sep 3, 2014·Journal of Neuroinflammation·David J Allison, David S Ditor
Sep 9, 2015·Frontiers in Psychiatry·Jennifer M Parrott, Jason C O'Connor
Oct 4, 2013·Oxidative Medicine and Cellular Longevity·Rafael Lugo-HuitrónVerónica Pérez-de la Cruz
May 27, 2014·Frontiers in Endocrinology·Nathalie CastanonLucile Capuron
May 18, 2016·Brain : a Journal of Neurology·Nathaniel S WoodlingKatrin I Andreasson
Jun 6, 2016·Journal of Neural Transmission·Saeed Sadigh-EteghadMahnaz Talebi
Sep 4, 2012·Journal of the Neurological Sciences·Lin TanLan Tan
Nov 22, 2015·Drug Discovery Today·Jason R SmithGilles J Guillemin
Aug 29, 2016·Brain Structure & Function·Judit HerédiLevente Gellért
Apr 5, 2017·Acta Crystallographica. Section D, Structural Biology·Lakshmi Swarna Mukhi PiduguEric A Toth
May 24, 2014·International Journal of Tryptophan Research : IJTR·Malin WennströmSophie Erhardt
Jul 7, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J KooJ J Wu
Jun 16, 2018·PloS One·Kalyanasundaram SubramanianPeter J Schaap
Jan 3, 2018·Molecular Neurobiology·Kuo-Hsuan ChangChiung-Mei Chen
Sep 19, 2018·Expert Opinion on Therapeutic Targets·Radhika SharmaAnurag Kuhad
Jan 12, 2019·British Journal of Pharmacology·Francis J HermanGiulio M Pasinetti
Apr 2, 2019·Frontiers in Neuroscience·Ole Kristian DrangeOle A Andreassen
Nov 30, 2012·European Archives of Psychiatry and Clinical Neuroscience·Markus J SchwarzHarald Hampel
Aug 4, 2019·Journal of Neurochemistry·Freek J H SorgdragerPeter P De Deyn
Dec 11, 2019·Journal of Clinical Medicine·Paulina WignerMichal Bijak
Jun 16, 2018·Neurology. Neuroimmunology and Neuroinflammation·Debra A FleischmanLisa L Barnes
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masaru TanakaLászló Vécsei
Mar 12, 2020·Antioxidants & Redox Signaling·Inês Marques-AleixoJosé Magalhães
Apr 12, 2020·Biomolecules·Marta González-SánchezEva Carro
Apr 5, 2020·International Journal of Molecular Sciences·Masaru TanakaLászló Vécsei
Jul 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronNathalie Castanon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved