Kynurenines, neurodegeneration and Alzheimer's disease.

Journal of Cellular and Molecular Medicine
Zsigmond Tamas KincsesLaszlo Vecsei

Abstract

Alzheimer's disease (AD) is one of the major causes of dementia. The pathogenesis of the disease is not entirely understood, but the amyloid β peptide (Aβ) and the formation of senile plaques seem to play pivotal roles. Oligomerization of the Aβ is thought to trigger a cascade of events, including oxidative stress, glutamate excitotoxicity and inflammation. The kynurenine (KYN) pathway is the major route for the metabolism of the essential amino acid tryptophan. Some of the metabolites of this pathway, such as 3-hydroxykynurenine and quinolinic acid, are known to have neurotoxic properties, whereas others, such as kynurenic acid, are putative neuroprotectants. Among other routes, the KYN pathway has been shown to be involved in AD pathogenesis, and connections to other known mechanisms have also been demonstrated. Oxidative stress, glutamate excitotoxicity and the neuroinflammation involved in AD pathogenesis have been revealed to be connected to the KYN pathway. Intervention at these key steps may serve as the aim of potential therapy.

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Citations

Dec 28, 2011·Journal of Neural Transmission·Tomasz ŻarnowskiMaciej Gasior
Oct 26, 2010·Amino Acids·Lukasz R KolodziejRichard O Williams
Apr 11, 2013·Translational Psychiatry·R Kaddurah-DaoukUNKNOWN Pharmacometabolomics Research Network
Oct 30, 2015·Cellular and Molecular Life Sciences : CMLS·Eszter BariczaGyörgy Nagy
Dec 16, 2010·Journal of Cellular and Molecular Medicine·Dénes ZádoriLászló Vécsei
Oct 14, 2014·Neurological Research·Han-Chang HuangZhao-Feng Jiang
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Zsigmond Tamas KincsesLászló Vécsei
Sep 4, 2012·Journal of the Neurological Sciences·Lin TanLan Tan
Dec 30, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·R AnandKiran Dip Gill
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·Joanna Kałużna-CzaplińskaGeir Bjørklund
Oct 17, 2013·The Journal of Biological Chemistry·Anne-Kristin StavrumMathias Ziegler
Aug 15, 2020·Journal of Internal Medicine·R BaumgartnerD F J Ketelhuth
Oct 30, 2016·Journal of Alzheimer's Disease : JAD·Viola Luca NemethLászló Vécsei
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Abhijeet SharmaAna C Pereira
Jan 7, 2021·International Journal of Molecular Sciences·Fanni TóthLászló Vécsei
May 4, 2020·Progress in Neurobiology·Michel MaitreAyikoe-Guy Mensah-Nyagan

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Methods Mentioned

BETA
transgenic
PCR

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