Kyrle's disease associated with HIV infection, diabetes, and chronic kidney disease

Indian Journal of Pathology & Microbiology
Geysa Maria Nogueira FariasGeraldo Bezerra da Silva Júnior

Abstract

Kyrle's disease (KD) is a rare skin pathology characterized by transepidermal elimination of abnormal keratin. The aim of this article is to report a rare case of KD associated with diabetes mellitus, chronic kidney disease, and HIV. A 51-year-old male patient complained of diarrhea for 8 months. He was submitted to HIV testing, which showed a positive result. He started antiretroviral therapy with zidovudine, lamivudine, and lopinavir. The diagnostic investigation was negative for opportunistic diseases. After 2 months, skin lesions started appearing, characterized by hyperchromic, pruritic macules and papules distributed in the trunk, back, and upper limbs. He also developed erythematous, scaly lesions in the facial region. A biopsy of the skin was performed, of which histopathological report consisted of perforating disorder, favoring a diagnosis of KD. Treatment with keratolytic soap (Actine) was started, with skin lesion improvement. In this reported case, it is possible that, in addition to diabetes and renal failure, HIV infection played an important role in the genesis of the lesions.

References

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Citations

Dec 27, 2019·International Journal of Dermatology·Pedro Miguel GarridoPaulo Filipe
Jan 11, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M ForouzandehG Yosipovitch
Oct 24, 2020·The Journal of Dermatology·Tamihiro KawakamiYasushi Suga

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