PMID: 7015366Mar 1, 1981Paper

L-5-Hydroxytryptophan-induced drinking in rats: possible mechanisms for induction

Pharmacology, Biochemistry, and Behavior
R M ThreatteD C Kikta

Abstract

Administration of L-5-hydroxytryptophan (25 mg/kg body weight, SC) to female rats resulted in copious drinking. The dipsogenic response to administration of L-5-hydroxytryptophan (5-HTP) was blocked by propranolol (6 mg/kg body weight, IP), a beta-adrenergic antagonist, and captopril (35 mg/kg body weight, IP), an angiotensin converting enzyme inhibitor. In addition, clonidine (12.5 and 25 microgram/kg body weight, IP), a central alpha-adrenergic agonist known to inhibit renin release, attenuated drinking during 1, 2 and 3 hours after 5-HTP was administered. These results suggest that 5-HTP-induced drinking is mediated by way of the renin-angiotensin system. Haloperidol (150 microgram/kg body weight, IP), a dopaminergic antagonist, also attenuated the dipsogenic response to administration of 5-HTP. In addition, incremental reductions in 5-HTP-induced drinking with increasing doses of spiperone (37.5 to 150 microgram/kg body weight, IP), a more potent dopaminergic antagonist, were demonstrated. Thus, the dipsogenic response to administration of 5-HTP to rats is dependent on both the renin-angiotensin system and an intact dopaminergic pathway.

References

Jun 1, 1978·Canadian Journal of Physiology and Pharmacology·M J Katovich, M J Fregly
May 1, 1974·European Journal of Pharmacology·F H Leenen, R H McDonald
Dec 1, 1971·Physiology & Behavior·K A Houpt, A N Epstein
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Nov 1, 1980·Brain Research Bulletin·M J FreglyR M Threatte

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Citations

Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·C C BarneyM J Fregly
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Jan 1, 1984·Pharmacology & Therapeutics·L M Fuller
Apr 1, 1984·Brain Research Bulletin·M J FreglyJ E Greenleaf
Apr 1, 1987·Brain Research Bulletin·N E RowlandM J Fregly
Mar 1, 1984·Appetite·K M WilsonM J Fregly

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