L-alpha-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
T S Haugstad, I A Langmoen

Abstract

The effect of the glutamate analogue L-alpha-aminoadipate (alpha AA) on the release of glutamate and gamma-aminobutyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivation caused a large release of glutamate and GABA. alpha AA added during energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 mM), whereas GABA release was unchanged. We speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by alpha AA.

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Citations

Dec 15, 2010·Journal of Applied Toxicology : JAT·Kiyoko BandoEiichiro Fukusaki
Jun 9, 1998·Annals of the New York Academy of Sciences·D J ReisD L Feinstein
Sep 9, 2016·Physiologia Plantarum·Zsolt GulyásGábor Kocsy

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