PMID: 8950003Nov 1, 1996Paper

L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid)

Behavioural Brain Research
C HölscherM J Rowan

Abstract

L-AP4, an agonist at the metabotrophic glutamate receptors 4, 6, 7, 8 and 9 produced a selective spatial learning impairment in a water maze as well as in an 8-arm maze task when injected i.c.v. (5 microliters of a 80 mM solution), a dose previously reported to block consolidation of long-term potentiation in vivo. Acquisition and recall of the spatial water-maze task, as measured by escape latency and quadrant bias, respectively, were impaired, whereas swim speed was not affected. In contrast, ability to perform a non-spatial control task was not impaired; latency to reach a visible escape platform was not delayed in L-AP4-treated animals. No behavioral difference was visible in the open field. MAP4, an antagonist of mGluRs mediating L-AP4 induced reduction of transmitter release, when administered pretraining i.c.v. (5 microliters of an 80 mM solution) did not affect motor activity in the open field test but did impair learning of both spatial tasks. In addition, swim speed was increased. However, injecting L-AP4 and MAP4 in combination at equimolar concentrations had no effect on learning in both spatial tasks or on swim speed in the water maze. Neither latency in the visible-platform test nor behavior in the open field was ...Continue Reading

References

Jan 1, 1992·Neuron·Y TanabeS Nakanishi
Jan 1, 1993·Trends in Pharmacological Sciences·D D Schoepp, P J Conn
Sep 1, 1994·Trends in Pharmacological Sciences·J Watkins, G Collingridge

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Citations

Sep 24, 1999·Journal of Neuroscience Research·C Hölscher
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Apr 22, 1999·Behavioural Brain Research·C Hölscher
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·C Hölscher
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·J Paige Adams, J David Sweatt
Feb 22, 2014·Journal of Neural Transmission·Clare Finlay, Susan Duty
Sep 27, 2015·European Journal of Pharmacology·YiMei ChenChristian Hölscher
Feb 27, 2007·European Journal of Pharmacology·Christian HolscherHanspeter A Mallot
Apr 8, 2010·European Journal of Pharmacology·Richard M O'ConnorJohn F Cryan

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