PMID: 8957355Dec 1, 1996Paper

L-arginine administration during reperfusion improves pulmonary function

The Annals of Thoracic Surgery
Y ShiraishiP A Chang

Abstract

Nitric oxide is crucial to the maintenance of vascular homeostasis. Because nitric oxide levels decline upon lung reperfusion, infusion of L-arginine, a nitric oxide precursor, during reperfusion might prove effective at ameliorating reperfusion injury. Neonatal piglet heart-lung blocks were preserved with Euro-Collins solution for 12 hours, rewarmed at room temperature for 1 hour, and reperfused for 10 minutes with either whole blood (n = 5), whole blood containing L-arginine (10 mmol/L; n = 6), or leukocyte-depleted blood (n = 6) on an isolated, blood-perfused, working heart-lung circuit. After the initial 10 minutes, all blocks received whole blood for 4 hours. Control blocks were continuously perfused on the circuit without intervening ischemia (n = 6). The partial pressure of oxygen in the whole blood group (113.8 +/- 33.1 mm Hg) was significantly less than in controls (417.3 +/- 6.2 mm Hg; p < 0.01). Lung compliance was significantly less in the whole blood group (0.8 +/- 0.2 mL/cm H2O) than in controls (2.9 +/- 0.4 mL/cm H2O; p < 0.01). The L-arginine and leukocyte-depleted blood groups showed no significant difference from controls. L-Arginine infusion during reperfusion improves pulmonary function, making it a simple a...Continue Reading

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Citations

Oct 30, 1999·The Annals of Thoracic Surgery·S HillingerW Weder
Dec 29, 1998·Transplantation Proceedings·S Massberg, K Messmer
Aug 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S HillingerR A Schmid
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T VainikkaH J Toivonen
Mar 7, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P SanderaR A Schmid
Apr 13, 2001·Acta Anaesthesiologica Scandinavica·M AngdinR Astudillo
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·O D SchneuwlyD R Morel
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Feb 28, 2001·Journal of Cardiac Surgery·J V Conte, W A Baumgartner
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Akihiro AoyamaToru Bando
Jun 29, 1999·The Journal of Surgical Research·K YoshidaM Haniuda
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·R A SchmidG Schoedon
Mar 7, 2020·Paediatric Drugs·Jahidur RashidCatherine M T Sherwin

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