L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation

Biochemical and Biophysical Research Communications
M E GoldL J Ignarro

Abstract

This study examined the actions of L-arginine, a putative precursor of endothelium-derived nitric oxide, and arginine analogs on endothelium-dependent relaxation of isolated rings of bovine pulmonary artery. L-Arginine did not consistently relax arterial rings unless rings were first rendered refractory to endothelium-dependent relaxation by pretreatment with 1 microM A23187 for 45 min. L-Arginine-elicited relaxation was endothelium-dependent, antagonized by oxyhemoglobin or methylene blue, and unaffected by indomethacin. L-Argininosuccinic acid caused endothelium-dependent contractions and irreversible inhibition of endothelium-dependent but not nitroglycerin-elicited relaxation, which was not overcome by addition of L-arginine. Inhibition of endothelium-dependent relaxation by L-NG-monomethyl arginine, however, was reversible and overcome by L-arginine. Therefore, endothelium-dependent relaxants may cause arginine depletion in endothelial cells and endogenous argininosuccinic acid may modulate the biosynthesis of endothelium-derived nitric oxide from arginine.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W P ArnoldF Murad
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I SakumaR Levi
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D J Stuehr, M A Marletta

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Citations

Jul 17, 1990·European Journal of Pharmacology·J A MitchellJ R Vane
Oct 31, 1991·Biochemical and Biophysical Research Communications·R G BogleG E Mann
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Mar 29, 2001·Progress in Neurobiology·H Wiesinger
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M E GoldL J Ignarro
May 1, 1992·Clinical and Experimental Pharmacology & Physiology·M J Rand, C G Li
Apr 1, 1991·British Journal of Pharmacology·H MoritokiS Takeuchi
May 1, 1994·British Journal of Pharmacology·M E Ward, S N Hussain
Apr 1, 1991·The Journal of Clinical Investigation·E RossitchJ P Cooke
Oct 1, 1992·The Journal of Clinical Investigation·M A CreagerJ P Cooke
Feb 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·R A Johns
May 16, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Z TodorovićS Vucković
Jun 29, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nini SkovgaardTobias Wang
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·R Tabrizchi, C R Triggle
Jul 4, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Jodie BrykPetar J Popovic
Nov 15, 2017·Nature Reviews. Urology·Fabiola Z Mónica, Edson Antunes
Dec 1, 1990·Circulation Research·X J GirerdM A Creager
Jul 1, 1996·Journal of Cardiovascular Pharmacology·J P Chin-DustingG L Jennings
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·R KellerP H van der Meide
Jul 20, 1999·Journal of Applied Physiology·B T Ameredes, M A Provenzano
Mar 30, 1990·Biochemical and Biophysical Research Communications·M HeckerJ R Vane
Jun 29, 1990·Biochemical and Biophysical Research Communications·A B EbeigbeL Criscione
Apr 30, 1990·Biochemical and Biophysical Research Communications·J M FukutoL J Ignarro
Oct 31, 1989·Biochemical and Biophysical Research Communications·M E GoldL J Ignarro

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