L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation

Kidney International
Lothar SchrammHarald H H W Schmidt

Abstract

The "L-arginine paradox" refers to situations where L-arginine (L-Arg) supplementation stimulates nitric oxide (NO) synthesis, despite saturating intracellular concentrations. This paradox is frequently observed in acute renal failure (ARF). First, the effects of L-Arg on renal function of rats with ARF were studied. Based on the promising results from these initial studies, the second part of our study searched for a form of ARF in humans that could be studied easily under conditions with little variance and yet was linked with endothelial dysfunction. Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients. In uranyl nitrate-induced ARF in rats the effects of L-Arg and L-NNA (inhibitor of nitric oxide synthase; NOS) on glomerular filtration rate (GFR), renal plasma flow (RPF), blood pressure (BP) and NOx (NO2- +NO3-) excretion were examined. Tissue L-Arg levels, NOS activities, immunodetection of NOS and superoxide dismutase (SOD), activities of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and xanthine oxidase, and nitrotyrosine immunoreactive protein (NT-IR) were determined and compared to sham operated animals. Secondly, in a randomized, double-blind ...Continue Reading

References

Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H H SchmidtF Murad
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Aug 1, 1990·Journal of the American Society of Nephrology : JASN·J B Kopp, P E Klotman
Jan 1, 1982·European Journal of Nuclear Medicine·W N TauxeL R Smith
Jan 1, 1980·The Journal of Clinical Investigation·P S AvasthiD Hay
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Aug 1, 1995·Nature Medicine·J L ZweierP Kuppusamy
Jan 1, 1995·Journal of the American Society of Nephrology : JASN·R S GastonD G Warnock
Sep 23, 1994·Cell·H H Schmidt, U Walter
Jan 1, 1994·Kidney International·I IchikawaT Yoshioka
Dec 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·M ButtiniH Boddeke
Sep 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·M S ChintalaE J Sybertz
May 15, 1996·The Journal of Clinical Investigation·E NoiriM S Goligorsky
Mar 1, 1996·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M S Wolin
Sep 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M YaqoobR W Schrier
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P WangJ L Zweier
May 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L A ToméA C Seguro
Jun 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M JerkićS B Vojvodić
Jul 29, 2000·Canadian Journal of Physiology and Pharmacology·J M ValdivielsoF Pérez Barriocanal
Jan 5, 2001·Transplant International : Official Journal of the European Society for Organ Transplantation·K LopauC Wanner
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Ingrid H C VosJaap A Joles

❮ Previous
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Citations

Nov 21, 2007·Bulletin of Experimental Biology and Medicine·V I KirpatovskiiD B Zorov
Jun 7, 2005·The Journal of Surgical Research·Vikas Chander, Kanwaljit Chopra
Jun 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura Vicente-VicenteAna Isabel Morales
Aug 13, 2009·Clinical and Experimental Pharmacology & Physiology·Mattias Carlström
Dec 22, 2004·Kidney International·Bertrand L JaberVaidyanathapuram S Balakrishnan
Mar 6, 2007·Nephron. Physiology·Ihab M MahmoudIbrahim El Desoky
Jan 13, 2006·BMC Genomics·Magali TaulanMarie-Catherine Romey
Dec 16, 2004·Environmental Health Perspectives·Magali TaulanMarie-Catherine Romey
Oct 31, 2012·International Journal of Molecular Sciences·Luis Aldámiz-Echevarría, Fernando Andrade
Aug 28, 2014·Amino Acids·Ada PopoloStefania Marzocco
Aug 20, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jiong ZhangYing Yao
Dec 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio Ponticelli
May 28, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Boris BetzReinhard Schneider
Oct 19, 2004·Seminars in Nephrology·Gianfranco GuarnieriRocco Barazzoni
Jul 2, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·John F TharakanLeticia Castillo
Dec 8, 2015·Canadian Journal of Physiology and Pharmacology·Dalia H El-KashefHatem A Salem
Sep 29, 2015·Antioxidants & Redox Signaling·Jeroen FrijhoffPietro Ghezzi
Nov 26, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P M SnijderH van Goor
Jul 15, 2004·Seminars in Nephrology·Ingrid H C VosTon J Rabelink
Sep 3, 2013·Renal Failure·Roman A Sukhovershin, Mikhail A Gilinsky
Mar 18, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anees A BandayFarah Khan
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Lingtak-Neander Chan
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Min JunVlado Perkovic
Sep 11, 2004·The Journal of Biological Chemistry·Kwon Moo ParkJoseph V Bonventre
Nov 23, 2007·American Journal of Physiology. Renal Physiology·Mattias CarlströmA Erik G Persson
May 21, 2020·International Journal of Molecular Sciences·Sorena B LoNirmala Parajuli
Aug 30, 2020·Pharmacological Reviews·Ana I CasasHarald H H W Schmidt
Oct 7, 2004·The Journal of Nutrition·Gautam Cherla, Edgar A Jaimes
Jun 3, 2021·Kidney Research and Clinical Practice·Sagar VermaVinant Bhargava
May 9, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Erik H KoritzinskyRobert L Fairchild

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