PMID: 12766119May 27, 2003Paper

L-arginine-induced vasodilation of the renal vasculature is not altered in hypertensive patients with type 2 diabetes

Diabetes Care
Christian DellesRoland E Schmieder

Abstract

Diabetes, arterial hypertension, hypercholesterolemia, and aging are associated with endothelial dysfunction in various vasculatures. Endothelium-dependent vasodilation of the renal vasculature cannot be easily assessed, but infusion of L-arginine, the substrate of endothelial nitric oxide synthase, leads to an increase in renal plasma flow (RPF) in humans. We have examined the effect of L-arginine infusion on renal hemodynamics in hypertensive patients with type 2 diabetes. Twenty-three elderly patients with type 2 diabetes (age, 65 +/- 6 years; HbA(1c), 7.8 +/- 1.6%) with coexisting arterial hypertension (158 +/- 19/83 +/- 11 mmHg) and elevated cholesterol levels (total cholesterol, 215 +/- 33 mg/dl) were examined. These patients were compared with a young and healthy reference group (n = 20; age, 26 +/- 2 years). The effect of L-arginine infusion (100 mg/kg over 30 min) on RPF and glomerular filtration rate were measured using the constant input clearance technique with p-aminohippurate and inulin, respectively. L-arginine infusion similarly influenced renal hemodynamics in patients and reference subjects: RPF increased by 7 +/- 11 and 7 +/- 11% in diabetic and reference subjects, respectively (P = NS). Other parameters of r...Continue Reading

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Citations

Jul 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus P SchneiderRoland E Schmieder
Aug 10, 2004·Current Opinion in Nephrology and Hypertension·Christian Delles, Roland E Schmieder
Jan 16, 2014·Cardiovascular Diabetology·Christian OttRoland E Schmieder
Jul 25, 2006·International Journal of Cardiology·Gerasimos SiasosChristodoulos Stefanadis
Sep 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rui ZhangRoshanak Rahimian

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