L-arginine metabolism in immune-mediated glomerulonephritis in the rat

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M KettelerN A Noble

Abstract

Low-protein diets slow the progression of some renal diseases. We recently found that dietary restriction of L-arginine markedly ameliorates disease in antithymocyte serum-induced glomerulonephritis in the rat, suggesting that L-arginine may play a key role in the beneficial effects of low-protein diets. L-arginine is metabolized by nitric oxide synthases to nitric oxide and L-citrulline or by arginase to urea and L-ornithine. L-ornithine is a precursor for polyamines, which are required for cell proliferation and for proline, an essential component of collagen. In a time course of disease, we found that inducible nitric oxide synthase gene expression and nitric oxide production were increased very early. Arginase activity was significantly increased until 5 days of disease. Ornithine decarboxylase, the rate-limiting step for polyamine synthesis, was increased at 3 days coincident with the onset of cell proliferation. Gene expression of ornithine aminotransferase, a proline synthetic enzyme, was increased from day 1, paralleling increased collagen synthesis. Thus, the three pathways of L-arginine metabolism are upregulated in a manner consistent with their possible roles in the cell lysis, cell proliferation, and collagen depos...Continue Reading

References

Jun 1, 1978·Metabolism: Clinical and Experimental·R J Smith, J M Phang
Nov 1, 1992·Kidney International·A JansenH T Cook
Oct 1, 1991·Kidney International·E Schulze-LohoffR B Sterzel
Dec 1, 1990·Kidney International·V CattellS Moncada
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A Barbul
Oct 1, 1986·Kidney International·T H HostetterB M Brenner
Aug 18, 1972·Biochimica Et Biophysica Acta·J T BrandtN Fausto
Oct 15, 1970·Biochimica Et Biophysica Acta·M Rojkind, L Diaz de León
May 1, 1980·Analytical Biochemistry·S I RennardP G Robey
Jan 1, 1981·Enzyme·V E Shih
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Feb 1, 1980·Analytical Biochemistry·U T Rüegg, A S Russell
Apr 1, 1994·Kidney International·A JansenV Cattell
Aug 1, 1993·The Journal of Experimental Medicine·N McCartney-FrancisS M Wahl
Feb 1, 1993·The American Journal of Physiology·S B PedersenB Richelsen
May 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A S LeveyP E Teschan
Dec 1, 1955·The Biochemical Journal·J E EASTOE

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Citations

Apr 8, 1998·The American Journal of Physiology·S N WaddingtonV Cattell
Nov 30, 2000·American Journal of Physiology. Renal Physiology·J SchwöbelM Mohaupt
Dec 11, 1999·Proceedings of the Association of American Physicians·M Noris, G Remuzzi
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M KettelerA Distler
Dec 5, 2015·Scientific Reports·Xuejuan LiJie Ding
Jul 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing MiaoJie Ding
Aug 5, 1998·The American Journal of Physiology·L G QueY C Huang
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Shunji IshizukaRoland C Blantz
Sep 6, 2000·Kidney International·M Ketteler, E Ritz
Feb 19, 2002·Kidney International·Markus KettelerEmile de Heer
May 1, 1997·Kidney International·H Peters, N A Noble

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