L-arginine plus drospirenone-ethinyl estradiol in the treatment of patients with PCOS: a prospective, placebo controlled, randomised, pilot study

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Cesare BattagliaStefano Venturoli

Abstract

To verify the effects of a pill containing drospirenone on the surrogate markers of arterial function and to evaluate the possible improvements induced by the addition of L-arginine. A prospective, placebo controlled, randomised, pilot study. University of Bologna. Twenty-eight young women with PCOS. Random submission to: drospirenone + ethinylestradiol+ a placebo (Group I; n = 15) or drospirenone + ethinylestradiol + oral L-arginine (4 g × 2/daily) (Group II, n = 13). Medical examination; blood measurement of nitrites/nitrates, biochemical and hormonal parameters; ultrasonographic analysis and colour Doppler evaluation of uterine, stromal ovarian and ophthalmic arteries; analysis of brachial artery flow-mediated vasodilatation; and 24-h ambulatory blood pressure monitoring. The above parameters were evaluated before and after 6 months. The low dose oral contraceptive containing drospirenone favoured a pre-hypertensive state. The L-arginine supplementation increased the circulating levels of nitrites/nitrates and improved the endothelium-dependent vasodilatation counteracting the negative effect of the contraceptive pill. Although, the present pilot study was conducted in a limited number of patients, it seems that the L-argini...Continue Reading

References

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Citations

May 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena MorottiCesare Battaglia
Jun 17, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cesare BattagliaPaolo G Artini
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahnaz SalmaniHossein Imani
Sep 28, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ellen T H C SmeetsPeter J Joris

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