L-arginine polymers inhibit the development of vein graft neointimal hyperplasia

The Journal of Thoracic and Cardiovascular Surgery
M H KownR C Robbins

Abstract

We sought to determine whether L -arginine polymer treatment of vein grafts enhances vascular production of nitric oxide and inhibits the development of neointimal hyperplasia. External jugular veins of New Zealand White rabbits (n = 42) were harvested; treated intraluminally for 15 minutes with phosphate-buffered saline solution or L -arginine polymer 5, 7, or 9 at either 10 or 100 micromol/L; and then grafted into the contralateral carotid artery. Rabbits were killed after 28 days, and 5-microm sections of vessels were stained with hematoxylin and scored for intima/media ratio by using computerized morphometric analysis. Separate veins were treated in a similar fashion with biotinylated polymers and phosphate-buffered saline solution to assess for translocation efficiencies. Finally, vein segments pretreated with either phosphate-buffered saline solution or L -arginine polymers were cultured in Dulbecco's modified Eagle's medium containing lipopolysaccharide (100 microg/mL) and interferon gamma (200 U/mL) for 48 hours before measuring nitric oxide levels by means of the Griess reaction. Biotinylated L -arginine polymers demonstrated a dose- and length-dependent uptake into intimal and medial cells of treated vessels. Nitric o...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Investigation·J P CookeM E Billingham
Aug 1, 1994·The Journal of Experimental Medicine·G K HanssonE Jennische
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·H E von der LeyenV J Dzau
Jun 1, 1995·Annals of Medicine·G J Dusting, P S Macdonald
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MorishitaV J Dzau
Jul 1, 1995·International Journal of Cardiology·J Vinten-JohansenZ Q Zhao
Oct 23, 1997·The Journal of Clinical Investigation·L L ShearsS M Pham
Jan 27, 1998·The Journal of Biological Chemistry·A EfthymiadisD A Jans
Jun 4, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G J FultonP O Hagen
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
Dec 22, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E MasiniP F Mannaioni
Nov 30, 2000·The Journal of Peptide Research : Official Journal of the American Peptide Society·D J MitchellJ B Rothbard
Aug 27, 2005·The Annals of Thoracic Surgery·Michael R DashwoodDomingos S R Souza
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

❮ Previous
Next ❯

Citations

Jul 26, 2002·Mediators of Inflammation·Shahida ShahanaGodfried M Roomans
Jun 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Vinit N VaruMelina R Kibbe
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Toshio HayashiGautam Chaudhuri
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Thomas Schachner
Aug 27, 2005·The Annals of Thoracic Surgery·Michael R DashwoodDomingos S R Souza
Jan 8, 2008·Journal of Vascular Surgery·Muneera R KapadiaMelina R Kibbe
Apr 17, 2012·Nitric Oxide : Biology and Chemistry·Matthew J AlefBrian S Zuckerbraun
Aug 8, 2007·Journal of Vascular Surgery·Sadaf S AhanchiMelina R Kibbe
Mar 27, 2012·Current Opinion in Pharmacology·Dominik WiedemannThomas Schachner
Dec 18, 2013·Nitric Oxide : Biology and Chemistry·Monica P RodriguezMelina R Kibbe
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·Helen O McCarthyDavid G Hirst
Dec 17, 2008·Biochemical and Biophysical Research Communications·Jingwei ShengCharles B Shoemaker
Oct 25, 2016·The Annals of Thoracic Surgery·Lavinia C WoodwardDavid P Taggart
Mar 19, 2014·Wilderness & Environmental Medicine·Lauren J AuerbachPaul S Auerbach
Nov 22, 2011·The Journal of Surgical Research·Melissa E HoggMelina R Kibbe
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Luis Leon, Howard P Greisler
Nov 30, 2007·Free Radical Biology & Medicine·Charles G PearceMelina R Kibbe
Jun 14, 2005·Medicinal Research Reviews·Ferenc HudeczGabriella Csík
Dec 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Ismail BouhoutLouis Paul Perrault
Oct 4, 2008·Biomacromolecules·Achala de MelAlexander M Seifalian
Apr 30, 2021·Pharmaceutical Development and Technology·Mehmet Birer, Füsun Acartürk
Dec 7, 2007·Vascular·Daniel A PopowichMelina R Kibbe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.