L-arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin

The American Journal of Physiology
B C SheridanD A Fullerton

Abstract

L-Arginine supplementation has been shown to restore endothelium-derived nitric oxide production in several pathological states. The purpose of this study was to examine the effect of administration of exogenous L-arginine on the endotoxin-induced lung neutrophil accumulation and impairment of endothelium-dependent guanosine 3',5'-cyclic monophosphate (cGMP)-mediated pulmonary vasorelaxation in rats. Endothelium-dependent relaxation was tested by receptor-dependent [acetylcholine (ACh)] and receptor-independent (A-23187) pathways. Endothelium-independent relaxation was tested with sodium nitroprusside (SNP). In isolated pulmonary arterial rings, concentration-response curves were generated with ACh, A-23187, and SNP (10(-9) to 10(-6) M) 4 h after endotoxin (500 micrograms/kg i.p.) with and without prior administration of L-arginine (300 mg/kg i.p.). Lung neutrophil accumulation was determined by myeloperoxidase (MPO) assay. After endotoxin, lung neutrophil accumulation was significantly increased (MPO activity, 3.8 +/- 0.4 vs. 0.8 +/- 0.1 units/g lung weight in control cells; P < 0.05), which was prevented by L-arginine treatment (MPO activity, 1.3 +/- 0.3 units/g lung weight; P < 0.05 vs. endotoxin). Endotoxin produced a signi...Continue Reading

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Citations

Jul 20, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharmila ChoudhuryMasao Takata
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y SongX Meng
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C M CalkinsR C McIntyre
Apr 17, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael R WilsonMasao Takata
Jan 10, 2009·The Journal of Trauma·Tangfeng LvYong Song

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