L-arginine protects against stress-induced gastric mucosal lesions by preserving gastric mucus

Clinical and Experimental Pharmacology & Physiology
Yoshiji Ohta, Keiji Nishida

Abstract

1. We have shown that exogenously administered L-arginine protects against water immersion restraint (WIR) stress-induced gastric mucosal lesions in rats through preservation of nitric oxide (NO) generation via constitutive nitric oxide synthase (cNOS), but not inducible nitric oxide synthase (iNOS), in the gastric mucosa. We have also indicated that impaired gastric mucus synthesis and secretion occur through a decrease in gastric cNOS activity in WIR-stressed rats. Therefore, in the presesnt study, we examined whether exogenously administered L-arginine exerts a protective effect against WIR stress-induced gastric mucosal lesions in rats through preservation of gastric mucus synthesis and secretion by NO generated from the administered amino acid via cNOS in the gastric mucosa. 2. Rats were subjected to WIR stress for 3 and 6 h. Either L-arginine (150-600 mg/kg) or D-arginine (600 mg/kg) was injected intraperitoneally 0.5 h prior to WIR stress. Either N(G)-monomethyl L-arginine (L-NMMA; 100 mg/kg) or N(G)-monomethyl D-arginine (D-NMMA; 100 mg/kg) was injected subcutaneously 0.5 h prior to WIR stress. Total NOS, cNOS, iNOS, nitrite and nitrate (breakdown products of NO), hexosamine (an index of gastric mucin) and adherent mucu...Continue Reading

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Citations

Sep 5, 2003·Physiology & Behavior·Houman HomayounAhmad Reza Dehpour
Jun 3, 2011·World Journal of Gastroenterology : WJG·Zhe ZhangChang-Ping Hu
May 31, 2011·Canadian Journal of Physiology and Pharmacology·Lingshan GouYi Liu
Oct 13, 2006·Current Opinion in Gastroenterology·Sushovan Guha, Jonathan D Kaunitz
Jun 12, 2020·World Journal of Gastroenterology : WJG·Dong-Qin ZhaoHai-Ji Sun

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