PMID: 8958162Jan 1, 1997Paper

L-Arginine reduces lipid peroxidation in patients with diabetes mellitus

Free Radical Biology & Medicine
B LubecG Lubec

Abstract

A current concept for the development of diabetic long-term complications is the involvement of oxidative stress, as, e.g., lipid peroxidation, in the diabetic state. Data published recently show also oxidative damage to DNA, which might be one factor for accelerated aging and diabetic microangiopathy. In our study we tested the hypothesis that L-arginine can reduce lipid peroxidation in patients with diabetes. We performed a blind placebo controlled study with crossing over two treatment periods for 3 months. Thirty patients with diabetes mellitus were randomly assigned to treatment group A (first treatment then placebo) and B (first placebo then treatment). Treatment consisted of two daily dosages of 1 g L-arginine free base. Lipid peroxidation as reflected by malondialdehyde was evaluated in urine using a standard HPLC assay. After 3 months of treatment there was a significant reduction in malondialdehyde levels in group A (p < .0032), whereas there was no difference compared to the baseline values after three months of placebo treatment in group B (p < .97). After crossing over, there was a significant reduction in malondialdehyde levels in group B (p < .0002). Group A showed a significant increase in malondialdehyde levels...Continue Reading

References

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May 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·S M MacRuryA C MacCuish
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Citations

Jul 12, 2005·Urological Research·Viswanathan PragasamPalaninathan Varalakshmi
Aug 28, 2014·Amino Acids·Ada PopoloStefania Marzocco
Dec 7, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nora M El-Sheikh, Fatma A Khalil
Dec 8, 2015·Canadian Journal of Physiology and Pharmacology·Dalia H El-KashefHatem A Salem
Apr 12, 2000·The American Journal of Medicine·Y Ohtsuka, J Nakaya
May 20, 2016·The Journal of Toxicological Sciences·Wei-Feng XuChun-Mei Li
Oct 12, 2016·Scientific Reports·Emi YamanoYosky Kataoka
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Viswanathan PragasamPalaninathan Varalakshmi
Jul 5, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Viswanathan PragasamPalaninathan Varalakshmi
Aug 6, 2004·Endocrine Reviews·Andrea M VincentEva L Feldman
Jul 28, 2009·Pakistan Journal of Biological Sciences : PJBS·F ShishehborS M Latifi
Aug 13, 2020·Biomedicines·Jessica GambardellaValentina Trimarco
Nov 7, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B LubecG Lubec

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