L-arginine suppresses lipopolysaccharide-induced expression of RANTES in glomeruli.

Journal of the American Society of Nephrology : JASN
U HaberstrohFriedrich Thaiss

Abstract

Endotoxemia leads to the infiltration of inflammatory cells in glomeruli and the tubulointerstitium of the kidney. The ultimate mechanisms for this infiltration, however, are not entirely clear. In this study, the glomerular formation of the chemokine RANTES (regulated upon activation normal T cell expressed and secreted) was examined in an in vivo model of endotoxemia to evaluate the role the local release of chemokines might play in the regulation of this inflammatory cell infiltrate. Since the beneficial effects of nitric oxide (NO) on immune-mediated tissue injury have been reported, we also examined possible interactions between the chemokine RANTES and the L-arginine/NO pathway. To induce endotoxemia, rats were injected intraperitoneally with lipopolysaccharide (LPS). Glomeruli were isolated over a 24-h time period, and RANTES was assessed by Northern blotting, a chemotactic assay, and a specific enzyme-linked immunosorbent assay. The chemokine release was associated with increased glomerular infiltration of monocytes/macrophages. LPS also stimulated the mRNA expression of inducible NO synthase and increased the release of nitrite into the supernatants of isolated glomeruli. Supplementation of L-arginine intake increased ...Continue Reading

Citations

Jan 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P C BaerH Geiger
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Ingrid H C VosJaap A Joles
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Gopala K RanganDavid C H Harris
May 7, 1999·Kidney International·M Kitamura, L G Fine
Nov 8, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I H C Vos, D M Briscoe
Feb 20, 2009·American Journal of Physiology. Renal Physiology·Catherine Meyer-SchwesingerTobias N Meyer
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya

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