L-ascorbic acid and alpha-tocopherol attenuates liver ischemia-reperfusion induced of cardiac function impairment

Transplantation Proceedings
C-C Hsu, J-J Wang

Abstract

The Pringle maneuver is a surgical procedure to minimize hemorrhage during hepatectomy, which however, can induce production of reactive oxygen species causing remote organ injury. We sought to study the impact of the Pringle maneuver on cardiac function as well as the protective effects of L-ascorbic acid and α-tocopherol pretreatments. Rats were divided into four study groups: L-ascorbic acid (60 mg/kg/d) or α-tocopherol (200 mg/kg/d), and surgical interventions (Sham-operated or liver ischemia-reperfusion [I/R]). Liver ischemia was performed by clamping the hepatic artery and portal vein for 30 minutes, followed by reperfusion by releasing the clamps for 2 hours. Cardiac function was evaluated by a high-fidelity pressure-volume catheter positioned in the left ventricle. Myocardial injury was assessed through plasma creatine kinase-MB (CKMB) and troponin I (cTnI). Cardiac lipid peroxidation and systemic hydroxyl radical levels were assessed by cardiac tissue malondialdehyde and plasma methylguanidine, respectively. Cardiac function was significantly depressed in the I/R group, where plasma CKMB and cTnI were markedly increased (P < .05). L-ascorbic acid and α-tocopherol pretreatments improved cardiac function and significantl...Continue Reading

References

Oct 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H Padh
Jan 1, 1995·Journal of Gastroenterology and Hepatology·H TsukamotoM Lin
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·V G NielsenD A Parks
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Feng GaoXin L Ma
May 26, 2007·Transplantation Proceedings·C F ChenC-C Chou
Oct 5, 2010·The Journal of Surgical Research·Yawei ChenXiaohua Xie

❮ Previous
Next ❯

Citations

Sep 4, 2014·Critical Care : the Official Journal of the Critical Care Forum·Heleen M Oudemans-van StraatenMonique C de Waard
Oct 1, 2014·The Journal of Surgical Research·Zoltán CzigányAttila Szijártó
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.