PMID: 8942418Dec 1, 1996Paper

L-carnitine and acetyl-L-carnitine status during hemodialysis with acetate in humans: a kinetic analysis

The American Journal of Clinical Nutrition
J M Jackson, H A Lee

Abstract

The effects of the acetate content of hemodialysis fluids on the relation between L-carnitine (free carnitine, cr FC) and acetyl-L-carnitine (AC) have not previously been examined in detail. The net fluxes of FC, AC, and acetate between intra- and extracellular pools during hemodialysis were calculated using a kinetic model with dialysates containing three concentrations of FC (0, 40, and 80 mumol/L) and either 40 or 3 mmol acetate/L. Radioenzymatic assays of FC and AC were optimized for use with samples taken during hemodialysis. Acetate stimulated a tissue uptake of FC (P < 0.05) that could exceed the rate of FC delivery and was related to the dialysate FC composition (P < 0.02). There were associated changes in tissue AC output. With dialysate containing 40 mmol acetate/L, AC tissue output was directly related to the dialysate FC composition (P < 0.05). The AC tissue output was less with dialysate containing 3 mmol acetate/L (P < 0.05) but the significant increase with the provision of FC in the dialysate was retained (P < 0.05). Hemodialysis may therefore represent an acute period of relative carnitine deficiency when regeneration of free coenzyme A from acetyl coenzyme A consequent to metabolism of acetate is limited.

Citations

Aug 12, 2003·Clinical Pharmacokinetics·Allan M Evans, Gianfranco Fornasini
Nov 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laurence VernezStephan Krähenbühl
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J Bommer
Oct 23, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jerry Yee
Dec 10, 1999·Annals of Clinical Biochemistry·J M Jackson

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