L-carnitine and cancer cachexia. I. L-carnitine distribution and metabolic disorders in cancer cachexia

Oncology Reports
Jarosław SzefelWiesława Lysiak-Szydłowska

Abstract

Cancer cachexia (CC), a progressive loss of body mass, is associated with decreased energy production. Abnormally low levels of L-carnitine (LC) in skeletal muscle means that mitochondrial β-oxidation of long-chain fatty acids (LCFA) does not occur efficiently in patients with CC. We assessed the influence of CC on LC distribution and the effects of parenteral lipid emulsions on plasma LC levels and urinary excretion. Fifty patients with CC were randomly assigned to total parenteral nutrition (TPN) with long-chain triglycerides (LCTs), or LCTs plus medium-chain triglycerides (MCTs) as 50/50. Patients were further separated into those with body-mass index (BMI) ≤ 19 kg/m(2) and BMI >19 kg/m(2). Plasma concentrations of total LC (TC) and free LC (FC) and their urinary excretion were measured, along with skeletal muscle LC levels. On average, plasma FC and TC were higher than reference values in all patients. Patients with BMI ≤ 19 kg/m(2) had lower plasma FC and TC than those with BMI >19 kg/m(2). Skeletal muscle FC in the BMI ≤ 19 kg/m(2) group was lower than reference value, but within the normal range in others. LC and FC urinary excretion was higher than reference values. Plasma LC and its urinary excretion were higher in pat...Continue Reading

Citations

Apr 24, 2013·Journal of Gastrointestinal Cancer·Estela Iraci RabitoJúlio Sérgio Marchini
Mar 17, 2015·Nutrition·Antonio Viganò, Jose A Morais
Jul 22, 2019·Healthcare·Toni MitchellKaren S Bishop

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