PMID: 16612469Apr 14, 2006Paper

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
A Borghi-SilvaD Costa

Abstract

The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 +/- 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 +/- 16 and 36 +/- 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 +/...Continue Reading

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Citations

Jan 28, 2009·World Journal of Pediatrics : WJP·Suna AsilsoySalih Kavukçu
Apr 24, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Audrey Borghi-SilvaDirceu Costa
Nov 3, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Audrey Borghi-SilvaDirceu Costa
Apr 20, 2013·Nutrients·Masayuki ItohKazutetsu Aoshiba
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May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Dec 2, 2014·COPD·Esther Barreiro, Joaquim Gea
Nov 27, 2015·Biochimica Et Biophysica Acta·Filippo IngogliaValeria Dall'Asta
Nov 11, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Marceli R LeiteDionei Ramos
May 26, 2009·Respiratory Medicine·Audrey Borghi-SilvaDirceu Costa
Mar 14, 2018·Nutrients·Roger FieldingAouatef Bellamine
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Feb 16, 2013·Journal of Applied Physiology·Fernanda RibeiroFrançois Maltais
Jun 8, 2021·Revue des maladies respiratoires·A HedhliB Dhahri

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