PMID: 8595631Nov 1, 1995Paper

L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts

Cardiovascular Research
T L BroderickD J Paulson

Abstract

Increasing myocardial carnitine content can improve heart function in patients with carnitine deficiency. We were interested in determining the effects of L-carnitine on cardiac function and substrate metabolism in a rat model of carnitine deficiency. Carnitine deficiency was induced in male Sprague-Dawley rats by supplementing the drinking water with 20 mM sodium pivalate. Control animals received an equimolar concentration of sodium bicarbonate. Following treatment, cardiac function and myocardial substrate utilization were determined in isolated working hearts perfused with glucose and relevant levels of fatty acids. To increase tissue levels of carnitine, hearts were perfused with 5 mM L-carnitine for a period of 60 min. Hearts from sodium pivalate-treated animals demonstrated a 60% reduction in total heart carnitine content, depressions in cardiac function and rates of palmitate oxidation, and elevated rates of glycolysis compared to control hearts. Treatment with L-carnitine increased total carnitine content and reversed the depression in cardiac function seen in carnitine-deficient hearts. However, this was not associated with any improvement in palmitate oxidation. Rates of glycolysis and glucose oxidation, on the other...Continue Reading

Citations

Oct 13, 2006·Annals of Hematology·Amal El-BeshlawyAli Taher
Aug 4, 1999·Journal of Diabetes and Its Complications·J I MaloneE Gilbert-Barness
Apr 15, 2011·Vascular Health and Risk Management·Carmen MingoranceMaría Dolores Herrera
Jan 5, 2014·Canadian Journal of Physiology and Pharmacology·Athina A StrilakouCharis A Liapi
Sep 25, 2012·Heart Failure Clinics·Bernard P C Kok, David N Brindley
Mar 25, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Françoise BrietC David Mazer
Mar 23, 2004·The Veterinary Clinics of North America. Small Animal Practice·Paul D Pion
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Jul 28, 2016·Nutrients·Edoardo SciattiMarco Metra
May 20, 2014·Diabetes Research and Clinical Practice·Xiuying ZhangLinong Ji
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Brian Schreiber
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuying C HwangRavichandran Ramasamy

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