l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ibrahim El Sharkwy, Mostafa Sharaf El-Din

Abstract

To evaluate the reproductive and metabolic effects of L-carnitine plus metformin in clomiphene citrate (CC) resistant obese polycystic ovary syndrome (PCOS) women. A double-blinded randomized controlled clinical trial, clomiphene-citrate resistant obese women were allocated randomly to receive CC plus metformin and L-carnitine (n = 138) or CC plus metformin and placebo (n = 136). The primary outcome was clinical pregnancy rate. The secondary outcomes were hormonal and metabolic profile changes in addition to ovulation and first trimester (13 weeks) miscarriage rates. Clomiphene-citrate, L-carnitine, and metformin group showed significant improvement in the menstrual regularity, ovulation rate, and pregnancy rate compared to CC plus metformin and placebo group (29% vs. 9%, 34.7% vs.11%, and 28.2% vs. 6.6%, respectively). No statistically significant difference in the miscarriage rate between the two groups (p = .08). After three months of treatment, the reduction in body mass index (BMI) was non-significant (p = .061) between both groups. The hormonal and metabolic parameters were more significantly improved in the L-carnitine group compared with the placebo group. l-Carnitine may act synergistically with metformin for improveme...Continue Reading

References

Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Nov 7, 2007·European Journal of Endocrinology·Susanne TanOnno E Janssen
Apr 2, 2008·Human Reproduction·Semin Melahat FenkciNedim Karagenc
Mar 25, 2009·Acta Obstetricia Et Gynecologica Scandinavica·Naci Kemal Kuşçu, Ahmet Var
May 5, 2010·Hypertension·Piero RuggenentiGiuseppe Remuzzi
Aug 21, 2010·Current Opinion in Obstetrics & Gynecology·Niki Katsiki, Apostolos I Hatzitolios
May 30, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Michael F CostelloHelena J Teede
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif
Jul 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Georgios ValsamakisGeorge Mastorakos
Feb 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Andrea RoeAnuja Dokras
Jul 13, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alaa M IsmailHossam H Thabet
Jun 11, 2015·Human Reproduction Update·Negar NaderpoorHelena J Teede
Sep 20, 2015·Molecular Genetics and Metabolism·Ayman W El-Hattab, Fernando Scaglia
Apr 8, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Samira Behboudi-GandevaniFereidoun Azizi
Jun 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Thomas M BarberStephen Franks
Aug 9, 2016·Medicinski pregled·Artur BjelicaJelena Dimitrijević
Nov 22, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Richard S Legro
Nov 22, 2016·Indian Journal of Endocrinology and Metabolism·Karoon ShahebrahimiMansour Rezaei
Feb 1, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Fatih CelikMine Kanat Pektas
Mar 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hamidreza JamilianZatollah Asemi
Jan 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Po-Kai YangHong-Nerng Ho

❮ Previous
Next ❯

Citations

Aug 28, 2020·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Sep 17, 2020·Reproductive Sciences·Jitender Kumar BhardwajPriyanka Saraf
Feb 2, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arezoo SheidaMaryam Eftekhar
Mar 26, 2021·The Cochrane Database of Systematic Reviews·Seyed Abdolvahab TaghaviFatemeh Bazarganipour
Oct 8, 2021·Molecular Reproduction and Development·Jiajian LiHuai L Feng
Oct 12, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dan LiaoCuifen Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.