l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function

Nutrients
Angelika K SawickaRobert A Olek

Abstract

Skeletal muscle wasting, associated with aging, may be regulated by the inflammatory cytokines as well as by insulin-like growth factor 1 (IGF-1). l-carnitine possesses anti-inflammatory properties and increases plasma IGF-1 concentration, leading to the regulation of the genes responsible for protein catabolism and anabolism. The purpose of the present study was to evaluate the effect of a 24-week l-carnitine supplementation on serum inflammatory markers, IGF-1, body composition and skeletal muscle strength in healthy human subjects over 65 years of age. Women between 65 and 70 years of age were supplemented for 24 weeks with either 1500 mg l-carnitine-l-tartrate or an isonitrogenous placebo per day in a double-blind fashion. Before and after the supplementation protocol, body mass and composition, as well as knee extensor and flexor muscle strength were determined. In the blood samples, free carnitine, interleukin-6, tumor necrosis factor-α, C-reactive protein and IGF-1 were determined. A marked increase in free plasma carnitine concentration was observed due to l-carnitine supplementation. No substantial changes in other parameters were noted. In the current study, supplementation for 24 weeks affected neither the skeletal m...Continue Reading

References

Jun 30, 1989·Biochemical and Biophysical Research Communications·M CostellS Grisolía
Oct 1, 1974·Journal of Chemical Education·A Bezkorovainy
Aug 1, 1984·European Journal of Clinical Investigation·A YoungM Crowe
Feb 19, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R RoubenoffC A Dinarello
Apr 26, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·V A HughesM A Fiatarone Singh
May 18, 2001·Journal of Applied Physiology·B H GoodpasterA B Newman
Oct 30, 2001·The Proceedings of the Nutrition Society·S W Coppack
May 2, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marjolein VisserTamara B Harris
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Aug 16, 2003·Gerontology·V Nimet Izgüt-UysalNarin Derin
Sep 13, 2003·Journal of Applied Physiology·Timothy J Doherty
Dec 10, 2003·Aging Clinical and Experimental Research·Mauro ZamboniOttavio Bosello
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matteo CesariLuigi Ferrucci
Jun 24, 2004·Journal of the American Geriatrics Society·Brenda W J H PenninxMarco Pahor
Sep 15, 2004·Molecular Aspects of Medicine·Alison SteiberCharles L Hoppel
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Ping LiMichael B Reid
Dec 22, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francis B StephensPaul L Greenhaff
Jun 6, 2006·The American Journal of Medicine·Laura A SchaapMarjolein Visser
Dec 19, 2008·Medicine and Science in Sports and Exercise·William G HopkinsJuri Hanin
Nov 17, 2010·Fundamental & Clinical Pharmacology·Giuseppe DerosaArrigo F G Cicero
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Renata SilvérioMarília Seelaender
Nov 17, 2012·Biological Chemistry·Riccardo CalvaniEmanuele Marzetti
Jun 8, 2013·The Journal of Physiological Sciences : JPS·Ewa ZiemannRadosław Laskowski
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·Bradley S GordonScot R Kimball
Nov 19, 2013·Clinics and Research in Hepatology and Gastroenterology·Kaan DemirorenIbrahim Halil Bahcecioglu
Jul 3, 2015·Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases·Simona L BuduiMauro Zamboni
Oct 29, 2015·Mediators of Inflammation·Domiziana CostamagnaFabio Penna

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Citations

Sep 23, 2020·Journal of the International Society of Sports Nutrition·Angelika K SawickaRobert A Olek
Oct 23, 2019·Oxidative Medicine and Cellular Longevity·Robert Antoni OlekWieslawa Lysiak-Szydlowska
Jan 10, 2019·Journal of Diabetes Research·Fernanda VacanteIleana Terruzzi

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