L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms

Cardiology
Ali Reza SeratiMohammad Reza Movahed

Abstract

L-Carnitine is a crucial component of activated fatty acid transport. The aim of this study was to evaluate the effect of L-carnitine on patients with a history of mild heart failure and diastolic dysfunction. Twenty-nine patients with a history of NYHA functional class II symptoms and ejection fraction >45% with documented grade 1 diastolic dysfunction on echocardiogram were randomized in blinded fashion to receive 1,500 mg of L-carnitine daily for 3 months in comparison to a no treatment group (31 patients). Baseline echocardiographic and follow-up measurements of diastolic parameters were assessed after 3 months. Important parameters of diastolic function improved in the L-carnitine group only: left atrial size (3.6 +/- 0.4 cm before treatment vs. 3.4 +/- 0.5 cm after treatment, p = 0.01); isovolemic relaxation time (127 +/- 26 ms before vs. 113 +/- 24 ms after treatment, p = 0.007); septal mitral E' velocity (0.064 +/- 0.01 m/s before vs. 0.074 +/- 0.01 m/s after treatment, p = 0.01), and lateral mitral E velocity (0.082 +/- 0.01 m/s before vs. 0.091 +/- 0.02 m/s after treatment, p = 0.006). Dyspnea also significantly improved in L-carnitine-treated patients. In patients with a history of diastolic heart failure, important ...Continue Reading

Citations

Oct 17, 2012·Current Heart Failure Reports·Selim R KrimHector Ventura
Jan 15, 2014·American Journal of Hypertension·Sonia ZambranoCarmen M Vázquez
Feb 18, 2016·Heart Failure Reviews·Michael J Goldenthal
Oct 27, 2011·Reproductive Toxicology·Jyotshnabala KanungoMerle G Paule
Jul 28, 2011·Congestive Heart Failure·John H LeeHector Ventura
Oct 29, 2021·Expert Review of Cardiovascular Therapy·Mikayla E Raddysh, Diego H Delgado

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