L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region

Neuropharmacology
Timo KirschsteinDirk Dietrich

Abstract

Specific agonists of metabotropic glutamate receptors (mGluRs) provide powerful tools to discriminate afferent fibers originating from different presynaptic neurons. The group II mGluR agonists L-CCG-I ((2S,1'S,2'S)-2-(2-carboxycyclopropyl)glycine) and DCG-IV ((2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine) are commonly used to distinguish between mossy fiber and associational-commissural (A/C) fiber input to the hippocampal CA3 region because only on the former group II mGluRs are expressed. Since previous reports indicated that L-CCG-I can activate group III mGluRs as well, we investigated whether L-CCG-I depresses A/C field potentials. L-CCG-I (10-300 microM) exhibited a significant dose-dependent and reversible reduction of A/C field potentials by 8 +/- 4% (10 microM), by 32 +/- 4% (100 microM, p < 0.001) and by 38 +/- 7% (300 microM, p < 0.05) that was accompanied by a concomitant increase in paired-pulse facilitation. Moreover, the selective group III antagonist (R,S)-alpha-methylserine-O-phosphate (MSOP; 100 microM) significantly reduced the field potential inhibition by L-CCG-I (100 microM) to 9 +/- 4% (p < 0.05). In contrast, DCG-IV did not affect A/C field potentials. In conclusion, the purported group II mGluR a...Continue Reading

References

Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A SalinR A Nicoll
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Jun 8, 2002·Science·Anis ContractorStephen F Heinemann
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kimberly A MooreDietmar Schmitz

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Citations

Nov 13, 2009·PloS One·Christopher S RexGary Lynch
Feb 18, 2011·Experimental Neurology·Andreas Toft SørensenMerab Kokaia
Aug 24, 2010·The European Journal of Neuroscience·Benjamin R RostDietmar Schmitz
Jul 29, 2009·Synapse·Maria Wostrack, Dirk Dietrich
May 16, 2006·Journal of the Neurological Sciences·Jorge UreMónica Perassolo
Dec 29, 2011·Neuropharmacology·Judith RohdeRüdiger Köhling

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