l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2 S formation

Brain, Behavior, and Immunity
Danqing XinZhen Wang

Abstract

We previously reported that l-Cysteine, an H2S donor, significantly alleviated brain injury after hypoxia-ischemic (HI) injury in neonatal mice. However, the mechanisms underlying this neuroprotective effect of l-Cysteine against HI insult remain unknown. In the present study, we tested the hypothesis that the protective effects of l-Cysteine are associated with glial responses and autophagy, and l-Cysteine attenuates synaptic injury as well as behavioral deficits resulting from HI. Consistent with our previous findings, we found that treatment with l-Cysteine after HI reduced early brain injury, improved behavioral deficits and synaptic damage, effects which were associated with an up-regulation of synaptophysin and postsynaptic density protein 95 expression in the lesioned cortex. l-Cysteine attenuated the accumulation of CD11b+/CD45high cells, activation of microglia and astrocytes and diminished HI-induced increases in reactive oxygen species and malondialdehyde within the lesioned cortex. In addition, l-Cysteine increased microtubule associated protein 1 light chain 3-II and Beclin1 expression, decreased p62 expression and phosphor-mammalian target of rapamycin and phosphor-signal transducer and activator of transcription ...Continue Reading

References

Feb 16, 1995·Brain Research. Developmental Brain Research·A McRaeH Hagberg
May 30, 1998·Archives of Pediatrics & Adolescent Medicine·J M LorenzN Paneth
Jan 7, 2000·Biochemical and Biophysical Research Communications·H Kimura
Dec 25, 2004·Behavioural Brain Research·Andrea LubicsIstván Lengvári
Oct 30, 2007·Nature Neuroscience·David J RossiClaudia Mohr
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Takahiro TakanoMaiken Nedergaard
Jan 1, 2008·Journal of Oncology·Valentina CalderaDavide Schiffer
Dec 17, 2009·Acta Neuropathologica·Michael V Sofroniew, Harry V Vinters
Oct 21, 2010·Physiological Reviews·Brinda RavikumarDavid C Rubinsztein
Feb 22, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammad R Al-Magableh, Joanne L Hart
Sep 17, 2013·Neurochemistry International·Hideo Kimura
Nov 23, 2013·Nature Protocols·Marianne LegerThomas Freret
Aug 26, 2014·Annals of Neurology·Vanessa GinetAnita C Truttmann
Oct 8, 2014·Physiological Reviews·Milos Pekny, Marcela Pekna
Feb 18, 2015·Nature Reviews. Neurology·Henrik HagbergPierre Gressens
Mar 10, 2015·Methods in Enzymology·Pradip Kumar KamatNeetu Tyagi
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Dongdong WuYanzhang Li
Aug 1, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C DesclouxA C Truttmann
Mar 21, 2017·Developmental Neuroscience·Guo ShaoXiangning Jiang
Jul 27, 2017·Medical Gas Research·Ju-Yi ZhangGang Chen
Dec 12, 2017·Frontiers in Cellular Neuroscience·Aleksey V YakovlevGuzel F Sitdikova

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Citations

Sep 26, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yong LiDaliao Xiao
Apr 5, 2020·Neural Regeneration Research·Ye XiongZhen Wang
Aug 14, 2019·Frontiers in Physiology·Lisa M HortensiusCaroline G M de Theije
Jul 18, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mohit KumarRajat Sandhir
Jan 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tingting LiZhen Wang
Dec 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Danqing XinZhen Wang
Aug 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xili ChuZhen Wang
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo

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