L-Dopa effect on frequency-dependent depression of the H-reflex in adult rats with complete spinal cord transection.

Brain Research Bulletin
Hao LiuEdgar Garcia-Rill

Abstract

This study investigated whether l-dopa (DOPA), locomotor-like passive exercise (Ex) using a motorized bicycle exercise trainer (MBET), or their combination in adult rats with complete spinal cord transection (Tx) preserves and restores low frequency-dependent depression (FDD) of the H-reflex. Adult Sprague-Dawley rats (n=56) transected at T8-9 had one of five treatments beginning 7 days after transection: Tx (transection only), Tx+Ex, Tx+DOPA, Tx+Ex+DOPA, and control (Ctl, no treatment) groups. After 30 days of treatment, FDD of the H-reflex was tested. Stimulation of the tibial nerve at 0.2, 1, 5, and 10Hz evoked an H-reflex that was recorded from plantar muscles of the hind paw. No significant differences were found at the stimulation rate of 1Hz. However, at 5Hz, FDD of the H-reflex in the Tx+Ex, Tx+DOPA and Ctl groups was significantly different from the Tx group (p<0.01). At 10Hz, all of the treatment groups were significantly different from the Tx group (p<0.01). No significant difference was identified between the Ctl and any of the treatment groups. These results suggest that DOPA significantly preserved and restored FDD after transection as effectively as exercise alone or exercise in combination with DOPA. Thus, there...Continue Reading

References

Jul 15, 1979·European Journal of Pharmacology·J W Commissiong, E M Sedgwick
May 17, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·T Magnusson
Jul 1, 1966·Acta Physiologica Scandinavica·N E AndénA Lundberg
Sep 1, 1996·Experimental Brain Research·J ErikssonE Jankowska
May 18, 1999·Archives of Physical Medicine and Rehabilitation·J W LittleR M Harris
Sep 1, 2000·Experimental Brain Research·S Schindler-Ivens, R K Shields
Apr 20, 2005·Spinal Cord·M M Adams, A L Hicks
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher A Hinckley, Lea Ziskind-Conhaim
Jan 12, 2007·Journal of Neurophysiology·David S HeisterEdgar Garcia-Rill
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francisco J UrbanoRodolfo R Llinás
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Wade KothmannJohn O'Brien

❮ Previous
Next ❯

Citations

May 5, 2016·Neurobiology of Aging·Guillaume CaronPatrick Decherchi
Apr 26, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Esther UdinaXavier Navarro
Jan 25, 2018·Current Diabetes Reports·Corinne Lee-KubliNigel A Calcutt
Jul 28, 2017·Journal of Neurotrauma·Sylvie LiabeufLaurent Vinay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here